biostudies-literatureZhu LNatural Science Foundation of Zhejiang ProvinceNational Natural Science Foundation of Chinae70318https://www.ebi.ac.uk/biostudies/studies/S-EPMC11903326biostudies-literatureUnknown31(3)<h4>Background and purpose</h4>Current guidelines for acute ischemic stroke (AIS) treatment recommend a lenient upper blood pressure (BP) threshold of 185/110 mmHg. However, stricter BP control has been reported to improve prognosis. This study aims to identify the optimal BP range following thrombolysis.<h4>Methods</h4>This observational study included 340 AIS patients treated with rt-PA thrombolysis at the First Affiliated Hospital of Wenzhou Medical University from December 2017 to December 2021. BP levels 24 h after thrombolysis were analyzed to determine their association with clinical outcomes. BP parameters included mean BP, variability (standard deviation (SD)), and decreased magnitudes. The primary outcome was the 90-day modified Rankin Scale (mRS) scores.<h4>Results</h4>Higher meCNS neuroscience & therapeuticsAssociation of Early Blood Pressure Levels and Outcomes in Ischemic Stroke Treated With Intravenous Thrombolysis: A Prospective Cohort Study.PMC11903326ZCLY24H090381901273Deng BLi YPang CZhang JZhu LXie JGao LChen YXie QYu HXu YfalseAssociation of Early Blood Pressure Levels and Outcomes in Ischemic Stroke Treated With Intravenous Thrombolysis: A Prospective Cohort Study.<h4>Background and purpose</h4>Current guidelines for acute ischemic stroke (AIS) treatment recommend a lenient upper blood pressure (BP) threshold of 185/110 mmHg. However, stricter BP control has been reported to improve prognosis. This study aims to identify the optimal BP range following thrombolysis.<h4>Methods</h4>This observational study included 340 AIS patients treated with rt-PA thrombolysis at the First Affiliated Hospital of Wenzhou Medical University from December 2017 to December 2021. BP levels 24 h after thrombolysis were analyzed to determine their association with clinical outcomes. BP parameters included mean BP, variability (standard deviation (SD)), and decreased magnitudes. The primary outcome was the 90-day modified Rankin Scale (mRS) scores.<h4>Results</h4>Higher me2025-01-01T00:00:00Z2025 Mar2025-04-04T01:28:25.924Z2025-04-04T01:28:25.924ZS-EPMC119033264007782810.1111/cns.70318