{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Cui B"],"pubmed_abstract":["The fruits of <i>Lycium ruthenicum</i> Murr. (<i>Solanaceae</i>) are employed in ethnomedicine and used as a functional food. Their antioxidant, anti-aging, and hypolipidemic activities have been investigated in modern research. This study indicated that the ethanolic extract of the fruits of <i>L. ruthenicum</i> Murr. (LRM) improved oxidative and heat stress tolerance, reduced the accumulation of lipofuscin, and retarded the aging process in <i>Caenorhabditis elegans</i> (<i>Rhabditidae</i>). Furthermore, the pharyngeal pumping rate and body length decreased under LRM treatment. Moreover, metabolomic analysis and the DPClusO algorithm revealed that LRM regulated a series of lifespan-related pathways centered on glycine, serine, and threonine metabolism. These results suggest that LRM prolongs the lifespan of <i>Caenorhabditis elegans</i> via dietary restriction. Moreover, feruloyl putrescine, a kind of polyamine, was found in differential metabolites, which may be the metabolite of caffeoyl-spermidine in LRM. These findings from this exploratory study offer a new insight into the roles of <i>L. ruthenicum</i> in anti-aging activity as a functional food."],"journal":["Frontiers in pharmacology"],"pagination":["1498280"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11903438"],"repository":["biostudies-literature"],"pubmed_title":["Anti-aging activities of an ethanolic extract of &lt;i&gt;Lycium ruthenicum&lt;/i&gt; in &lt;i&gt;Caenorhabditis elegans&lt;/i&gt; based on metabonomic analysis."],"pmcid":["PMC11903438"],"pubmed_authors":["Shan Y","Qiao X","Liu L","Feng X","Xu S","Shi T","Yin M","Cui B"],"additional_accession":[]},"is_claimable":false,"name":"Anti-aging activities of an ethanolic extract of &lt;i&gt;Lycium ruthenicum&lt;/i&gt; in &lt;i&gt;Caenorhabditis elegans&lt;/i&gt; based on metabonomic analysis.","description":"The fruits of <i>Lycium ruthenicum</i> Murr. (<i>Solanaceae</i>) are employed in ethnomedicine and used as a functional food. Their antioxidant, anti-aging, and hypolipidemic activities have been investigated in modern research. This study indicated that the ethanolic extract of the fruits of <i>L. ruthenicum</i> Murr. (LRM) improved oxidative and heat stress tolerance, reduced the accumulation of lipofuscin, and retarded the aging process in <i>Caenorhabditis elegans</i> (<i>Rhabditidae</i>). Furthermore, the pharyngeal pumping rate and body length decreased under LRM treatment. Moreover, metabolomic analysis and the DPClusO algorithm revealed that LRM regulated a series of lifespan-related pathways centered on glycine, serine, and threonine metabolism. These results suggest that LRM prolongs the lifespan of <i>Caenorhabditis elegans</i> via dietary restriction. Moreover, feruloyl putrescine, a kind of polyamine, was found in differential metabolites, which may be the metabolite of caffeoyl-spermidine in LRM. These findings from this exploratory study offer a new insight into the roles of <i>L. ruthenicum</i> in anti-aging activity as a functional food.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-04-03T23:26:09.682Z","creation":"2025-04-03T23:26:09.682Z"},"accession":"S-EPMC11903438","cross_references":{"pubmed":["40083385"],"doi":["10.3389/fphar.2025.1498280"]}}