biostudies-literatureUnknown51(1)Glynn R<h4>Purpose</h4>Major trauma is a leading cause of acute morbidity and mortality. While injury severity drives much of the associated burden, pre-existing comorbidities may influence both acute management and long-term outcomes. This scoping review examines the impact of comorbidities on trauma outcomes.<h4>Methods</h4>Embase, Medline, CINAHL, Cochrane Library, and PubMed were systematically searched from inception to 22/04/2021 (update 22/03/2024). Studies investigating comorbidities as risk factors for adverse outcomes in adults (≥ 18 years) with major trauma were included.<h4>Results</h4>Of 5448 studies identified, 33 met inclusion criteria. No studies examined whether comorbidities increases the risk of major trauma, and only two studies investigated the development of comorbidities poEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society133https://www.ebi.ac.uk/biostudies/studies/S-EPMC11903538biostudies-literatureMajor trauma and comorbidity: a scoping review.PMC11903538Glynn REdwards FLaupland KBGardiner BWullschleger MfalseMajor trauma and comorbidity: a scoping review.<h4>Purpose</h4>Major trauma is a leading cause of acute morbidity and mortality. While injury severity drives much of the associated burden, pre-existing comorbidities may influence both acute management and long-term outcomes. This scoping review examines the impact of comorbidities on trauma outcomes.<h4>Methods</h4>Embase, Medline, CINAHL, Cochrane Library, and PubMed were systematically searched from inception to 22/04/2021 (update 22/03/2024). Studies investigating comorbidities as risk factors for adverse outcomes in adults (≥ 18 years) with major trauma were included.<h4>Results</h4>Of 5448 studies identified, 33 met inclusion criteria. No studies examined whether comorbidities increases the risk of major trauma, and only two studies investigated the development of comorbidities po2025-01-01T00:00:00Z2025 Mar2025-04-03T23:23:53.366Z2025-04-03T23:23:53.366ZS-EPMC119035384007487210.1007/s00068-025-02805-x