{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["El-Sheikh M"],"pubmed_abstract":["<h4>Background</h4>Increased BMI is paradoxically associated with improved survival among patients with acute heart failure (AHF). However, the impact of different nutritional status on this obesity paradox on 1-year mortality is underreported. The prognostic nutritional index is a simple tool to assess nutrition status.<h4>Methods</h4>From 10,027 emergency department admissions at the Amager and Hvidovre Hospital, Copenhagen University Hospital in Denmark, all patients with AHF were identified. Patients were categorised by BMI (normal: 18.5-24.9 kg/m<sup>2</sup>, overweight: 25-29.9 kg/m<sup>2</sup>, obese: ≥30 kg/m<sup>2</sup>) and nutritional status using the prognostic nutritional index (malnourished: <38, well-nourished: ≥38). Kaplan- Meier curves analysed cumulative survival, and Cox regression examined associations between BMI, nutritional status and outcomes, expressed as HR and 95% CI.<h4>Results</h4>Among 383 AHF patients (median age 76 years), 41.3% were malnourished and 58.7% well nourished. In the well-nourished group, obesity was inversely associated with 1-year mortality (adjusted HR 0.48; 95% CI [0.24-0.95]; p=0.035). However, this correlation disappeared in the malnourished group (adjusted HR 1.08; 95% CI [0.59-2.00]; p=0.798). Mortality rates were significantly lower in the well-nourished group among patients with overweight and obesity.<h4>Conclusion</h4>Obesity was associated with reduced 1-year mortality only in AHF patients with good nutritional status, while in malnourished patients, obesity was not associated with 1-year mortality. The prognosis in patients with AHF depends on both the presence of obesity and their nutritional status, highlighting the need for nutritional assessment for risk stratification."],"journal":["Cardiac failure review"],"pagination":["e03"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11904423"],"repository":["biostudies-literature"],"pubmed_title":["Associations of Obesity and Prognostic Nutritional Index on 1-Year Mortality in Patients with Acute Heart Failure."],"pmcid":["PMC11904423"],"pubmed_authors":["Kandiah A","Tonning SH","Taraldsen IA","Andersen O","Hove JD","Wisborg FD","Grand J","El-Sheikh M","El Caidi NO"],"additional_accession":[]},"is_claimable":false,"name":"Associations of Obesity and Prognostic Nutritional Index on 1-Year Mortality in Patients with Acute Heart Failure.","description":"<h4>Background</h4>Increased BMI is paradoxically associated with improved survival among patients with acute heart failure (AHF). However, the impact of different nutritional status on this obesity paradox on 1-year mortality is underreported. The prognostic nutritional index is a simple tool to assess nutrition status.<h4>Methods</h4>From 10,027 emergency department admissions at the Amager and Hvidovre Hospital, Copenhagen University Hospital in Denmark, all patients with AHF were identified. Patients were categorised by BMI (normal: 18.5-24.9 kg/m<sup>2</sup>, overweight: 25-29.9 kg/m<sup>2</sup>, obese: ≥30 kg/m<sup>2</sup>) and nutritional status using the prognostic nutritional index (malnourished: <38, well-nourished: ≥38). Kaplan- Meier curves analysed cumulative survival, and Cox regression examined associations between BMI, nutritional status and outcomes, expressed as HR and 95% CI.<h4>Results</h4>Among 383 AHF patients (median age 76 years), 41.3% were malnourished and 58.7% well nourished. In the well-nourished group, obesity was inversely associated with 1-year mortality (adjusted HR 0.48; 95% CI [0.24-0.95]; p=0.035). However, this correlation disappeared in the malnourished group (adjusted HR 1.08; 95% CI [0.59-2.00]; p=0.798). Mortality rates were significantly lower in the well-nourished group among patients with overweight and obesity.<h4>Conclusion</h4>Obesity was associated with reduced 1-year mortality only in AHF patients with good nutritional status, while in malnourished patients, obesity was not associated with 1-year mortality. The prognosis in patients with AHF depends on both the presence of obesity and their nutritional status, highlighting the need for nutritional assessment for risk stratification.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-04-04T00:33:06.769Z","creation":"2025-04-04T00:33:06.769Z"},"accession":"S-EPMC11904423","cross_references":{"pubmed":["40083652"],"doi":["10.15420/cfr.2024.35"]}}