biostudies-literatureUnknown11(4)Lee WJ<h4>Objectives</h4>We investigated the domain-specific patterns of the association of segmental brain volume and white matter signal abnormality (WMSA) volume with longitudinal changes in cognitive function.<h4>Methods</h4>Participants from an institutional health check-up program who were aged >50 years, did not have a confirmed central nervous system disorder and underwent baseline and follow-up evaluations for cognitive function and brain MRI with an interval of at least 1 year were included. Cognitive function was assessed using the Consortium to Establish a Registry for Alzheimer's Disease-Korean version (CERAD-K) assessment battery. Performance changes in each cognitive domain were analyzed for associations with serial data of segmental brain volume and WMSA volume.<h4>Results</h4>A total of 190 subjects were included (115 [60.1 %] females, mean age 68.2 ± 8.2 years [range 50-82 years]). Declines in global cognition were associated with lower baseline (<i>P=</i>0.001) and decreasing volumes (<i>P=</i>0.001) of the hippocampus and amygdala and with increasing total WMSA volumes (<i>P=</i>0.008). Declines in the executive function domain were associated with lower baseline volumes of the hippocampus and amygdala (<i>P</i> = 0.018) and with increasing total WMSA volumes (<i>P=</i>0.015). Declines in the language function and the verbal learning domains were associated with lower baseline (<i>P=</i>0.009 and <i>P=</i>0.002, respectively) and decreasing volumes (<i>P=</i>0.008 and <i>P=</i>0.001, respectively) of the hippocampus and amygdala. Decline in the memory recall was associated with higher total WMSA volumes at baseline (<i>P=</i>0.014). Declines in the recognition memory domains were associated with lower baseline hippocampus and amygdala volume (<i>P</i> = 0.020) and with increases in total WMSA volumes (<i>P=</i>0.012).<h4>Conclusions</h4>The segmental brain volume and the WMSA volume parameters have domain-specific associations with longitudinal cognitive changes, which might reflect the different dependence on the brain reserve according to the cognitive domains.Heliyone42536https://www.ebi.ac.uk/biostudies/studies/S-EPMC11904571biostudies-literatureDomain-specific longitudinal associations between brain volume, white matter lesions, and cognitive function changes.PMC11904571Lee SKPark KIJung KHLee WJChu KfalseDomain-specific longitudinal associations between brain volume, white matter lesions, and cognitive function changes.<h4>Objectives</h4>We investigated the domain-specific patterns of the association of segmental brain volume and white matter signal abnormality (WMSA) volume with longitudinal changes in cognitive function.<h4>Methods</h4>Participants from an institutional health check-up program who were aged >50 years, did not have a confirmed central nervous system disorder and underwent baseline and follow-up evaluations for cognitive function and brain MRI with an interval of at least 1 year were included. Cognitive function was assessed using the Consortium to Establish a Registry for Alzheimer's Disease-Korean version (CERAD-K) assessment battery. Performance changes in each cognitive domain were analyzed for associations with serial data of segmental brain volume and WMSA volume.<h4>Results</h4>A total of 190 subjects were included (115 [60.1 %] females, mean age 68.2 ± 8.2 years [range 50-82 years]). Declines in global cognition were associated with lower baseline (<i>P=</i>0.001) and decreasing volumes (<i>P=</i>0.001) of the hippocampus and amygdala and with increasing total WMSA volumes (<i>P=</i>0.008). Declines in the executive function domain were associated with lower baseline volumes of the hippocampus and amygdala (<i>P</i> = 0.018) and with increasing total WMSA volumes (<i>P=</i>0.015). Declines in the language function and the verbal learning domains were associated with lower baseline (<i>P=</i>0.009 and <i>P=</i>0.002, respectively) and decreasing volumes (<i>P=</i>0.008 and <i>P=</i>0.001, respectively) of the hippocampus and amygdala. Decline in the memory recall was associated with higher total WMSA volumes at baseline (<i>P=</i>0.014). Declines in the recognition memory domains were associated with lower baseline hippocampus and amygdala volume (<i>P</i> = 0.020) and with increases in total WMSA volumes (<i>P=</i>0.012).<h4>Conclusions</h4>The segmental brain volume and the WMSA volume parameters have domain-specific associations with longitudinal cognitive changes, which might reflect the different dependence on the brain reserve according to the cognitive domains.2025-01-01T00:00:00Z2025 Feb2025-04-04T00:32:39.409Z2025-04-04T00:32:39.409ZS-EPMC119045714008402810.1016/j.heliyon.2025.e42536