{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["81"],"submitter":["Zhang H"],"pubmed_abstract":["Ruminal dysbiosis-induced liver injury is prevalent in dairy cows, yet its underlying mechanisms remain incompletely understood. Ferroptosis, a newly identified form of programmed cell death distinct from apoptosis and necrosis, has been implicated in various liver diseases by emerging studies. In the present study, lipopolysaccharide (LPS) and γ-D-glutamyl-meso-diaminopimelic acid (iE-DAP) were employed to establish in vitro and in vivo models of liver injury using bovine hepatocytes and mice, respectively. It was observed that noncytotoxic iE-DAP alone did not influence lipid peroxidation or GPX4, but exacerbated LPS-induced ferroptosis and hepatocyte injury. Notably, co-treatment with LPS and iE-DAP (LPS/iE-DAP)-induced hepatocyte injury was mitigated by intervention with the ferroptosi"],"journal":["Redox biology"],"pagination":["103557"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11904602"],"repository":["biostudies-literature"],"pubmed_title":["Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux."],"pmcid":["PMC11904602"],"pubmed_authors":["Li X","Zhou S","Ma N","Zhang H","Meng M","Song X","Shen X","Shi H","Chang G"],"additional_accession":[]},"is_claimable":false,"name":"Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux.","description":"Ruminal dysbiosis-induced liver injury is prevalent in dairy cows, yet its underlying mechanisms remain incompletely understood. Ferroptosis, a newly identified form of programmed cell death distinct from apoptosis and necrosis, has been implicated in various liver diseases by emerging studies. In the present study, lipopolysaccharide (LPS) and γ-D-glutamyl-meso-diaminopimelic acid (iE-DAP) were employed to establish in vitro and in vivo models of liver injury using bovine hepatocytes and mice, respectively. It was observed that noncytotoxic iE-DAP alone did not influence lipid peroxidation or GPX4, but exacerbated LPS-induced ferroptosis and hepatocyte injury. Notably, co-treatment with LPS and iE-DAP (LPS/iE-DAP)-induced hepatocyte injury was mitigated by intervention with the ferroptosi","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-04-04T00:08:26.944Z","creation":"2025-04-04T00:08:26.944Z"},"accession":"S-EPMC11904602","cross_references":{"pubmed":["39986118"],"doi":["10.1016/j.redox.2025.103557"]}}