biostudies-literatureUnknown8(3)Rousseau JF<h4>Importance</h4>Tenecteplase is an alternative to alteplase for emergency treatment of acute ischemic stroke. However, limited data are available comparing their clinical effectiveness in routine clinical practice.<h4>Objective</h4>To compare short-term effectiveness and safety outcomes for patients with ischemic stroke treated with intravenous tenecteplase vs alteplase.<h4>Design, setting, and participants</h4>This comparative effectiveness study used data prospectively collected from July 1, 2020, through June 30, 2022, from the Get With The Guidelines-Stroke registry.<h4>Exposure</h4>Consecutive patients with ischemic stroke treated with either tenecteplase or alteplase within 4.5 hours from last known well time were included.<h4>Main outcomes and measures</h4>The primary end point wJAMA network opene250548https://www.ebi.ac.uk/biostudies/studies/S-EPMC11904722biostudies-literatureShort-Term Safety and Effectiveness for Tenecteplase and Alteplase in Acute Ischemic Stroke.PMC11904722Rousseau JFMesse SRSchwamm LHFonarow GCXian YSheth KNSilva GSAlhanti BSaver JLMac Grory BSmith EEWeber JMWarach SJMullen MTfalseShort-Term Safety and Effectiveness for Tenecteplase and Alteplase in Acute Ischemic Stroke.<h4>Importance</h4>Tenecteplase is an alternative to alteplase for emergency treatment of acute ischemic stroke. However, limited data are available comparing their clinical effectiveness in routine clinical practice.<h4>Objective</h4>To compare short-term effectiveness and safety outcomes for patients with ischemic stroke treated with intravenous tenecteplase vs alteplase.<h4>Design, setting, and participants</h4>This comparative effectiveness study used data prospectively collected from July 1, 2020, through June 30, 2022, from the Get With The Guidelines-Stroke registry.<h4>Exposure</h4>Consecutive patients with ischemic stroke treated with either tenecteplase or alteplase within 4.5 hours from last known well time were included.<h4>Main outcomes and measures</h4>The primary end point w2025-01-01T00:00:00Z2025 Mar2026-06-06T23:41:34.747Z2025-04-22T07:25:23.806ZS-EPMC119047224007243410.1001/jamanetworkopen.2025.0548