{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Bianchi A"],"funding":["Université de Haute-Alsace","Swiss National Science Foundation","Université de Fribourg","Université de Strasbourg"],"pubmed_abstract":["The binding of metal ions in proteins is often crucial for their function and hence for life. Silver is known to possess antimicrobial properties, yet little is known about the exact molecular mechanism of action. Based on the silver binding tetrapeptide moieties HX<sub>1</sub>X<sub>2</sub>M, and MX<sub>1</sub>X<sub>2</sub>H found in the silver efflux pump protein SilE, we studied the influence of the individual amino acids X<sub>1</sub> and X<sub>2</sub> and found trends that may be important in general metal ion binding in proteins."],"journal":["Chemical communications (Cambridge, England)"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11904771"],"repository":["biostudies-literature"],"pubmed_title":["Toward predicting silver ion binding in proteins."],"pmcid":["PMC11904771"],"funding_grant_id":["2000020_172777","2000020_204215","g2023a142c/g","g2024a236c/g"],"pubmed_authors":["Manciocchi L","Spichty M","Bianchi A","Fromm KM","Marquenet F"],"additional_accession":[]},"is_claimable":false,"name":"Toward predicting silver ion binding in proteins.","description":"The binding of metal ions in proteins is often crucial for their function and hence for life. Silver is known to possess antimicrobial properties, yet little is known about the exact molecular mechanism of action. Based on the silver binding tetrapeptide moieties HX<sub>1</sub>X<sub>2</sub>M, and MX<sub>1</sub>X<sub>2</sub>H found in the silver efflux pump protein SilE, we studied the influence of the individual amino acids X<sub>1</sub> and X<sub>2</sub> and found trends that may be important in general metal ion binding in proteins.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-20T00:08:53.742Z","creation":"2025-04-20T00:08:53.742Z"},"accession":"S-EPMC11904771","cross_references":{"pubmed":["40079190"],"doi":["10.1039/d4cc06612j"]}}