{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["van der Pijl R"],"funding":["NHLBI NIH HHS","NIAMS NIH HHS"],"pagination":["e012083"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11905908"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(3)"],"pubmed_abstract":["<h4>Background</h4>TTN (titin) is the third myofilament type of the cardiac sarcomere and performs important functions that include generating passive tension. Changes in TTN expression are associated with cardiac dysfunction, and TTN is one of the main genes linked to dilated cardiomyopathy (DCM). DCM is frequently associated with changes in the expression of N2BA (compliant cardiac TTN isoform), 1 of the 2 major TTN isoforms found in the heart (the other isoform being the N2B [stiff cardiac TTN isoform]). Whether altered expression of N2BA TTN causes DCM or is a secondary change remains unclear.<h4>Methods</h4>Here, we present a mouse model, the Ttn<sup>Δ112-158</sup> model, which specifically shortens the proline, glutamate, valine, lysine region of the N2BA isoform.<h4>Results</h4>Echo"],"journal":["Circulation. Heart failure"],"pubmed_title":["Importance of N2BA Titin in Maintaining Cardiac Homeostasis and Its Role in Dilated Cardiomyopathy."],"pmcid":["PMC11905908"],"funding_grant_id":["R01 AR073179","R01 HL171047","R35 HL144998"],"pubmed_authors":["Granzier H","Saripalli C","Hermanson K","Labeit S","Methawasin M","Strom J","Kolb J","Brynnel O","Smith JE","Slater R","Nusayr E","Gohlke J","van der Pijl R","Hourani Z"],"additional_accession":[]},"is_claimable":false,"name":"Importance of N2BA Titin in Maintaining Cardiac Homeostasis and Its Role in Dilated Cardiomyopathy.","description":"<h4>Background</h4>TTN (titin) is the third myofilament type of the cardiac sarcomere and performs important functions that include generating passive tension. Changes in TTN expression are associated with cardiac dysfunction, and TTN is one of the main genes linked to dilated cardiomyopathy (DCM). DCM is frequently associated with changes in the expression of N2BA (compliant cardiac TTN isoform), 1 of the 2 major TTN isoforms found in the heart (the other isoform being the N2B [stiff cardiac TTN isoform]). Whether altered expression of N2BA TTN causes DCM or is a secondary change remains unclear.<h4>Methods</h4>Here, we present a mouse model, the Ttn<sup>Δ112-158</sup> model, which specifically shortens the proline, glutamate, valine, lysine region of the N2BA isoform.<h4>Results</h4>Echo","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-07-16T23:32:40.79Z","creation":"2026-07-12T03:11:17.702Z"},"accession":"S-EPMC11905908","cross_references":{"pubmed":["39932400"],"doi":["10.1161/circheartfailure.124.012083","10.1161/CIRCHEARTFAILURE.124.012083"]}}