{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kang J"],"funding":["BLRD VA","NCATS NIH HHS","NICHD NIH HHS","NIA NIH HHS","NCRR NIH HHS","NIMH NIH HHS","NHLBI NIH HHS","NHGRI NIH HHS","NINDS NIH HHS","NIGMS NIH HHS"],"pagination":["608-619"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11905962"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["181(7)"],"pubmed_abstract":["<h4>Objective</h4>Treatment-resistant depression (TRD) occurs in roughly one-third of all individuals with major depressive disorder (MDD). Although research has suggested a significant common variant genetic component of liability to TRD, with heritability estimated at 8% when compared with non-treatment-resistant MDD, no replicated genetic loci have been identified, and the genetic architecture of TRD remains unclear. A key barrier to this work has been the paucity of adequately powered cohorts for investigation, largely because of the challenge in prospectively investigating this phenotype. The objective of this study was to perform a well-powered genetic study of TRD.<h4>Methods</h4>Using receipt of electroconvulsive therapy (ECT) as a surrogate for TRD, the authors applied standard ma"],"journal":["The American journal of psychiatry"],"pubmed_title":["Genome-Wide Association Study of Treatment-Resistant Depression: Shared Biology With Metabolic Traits."],"pmcid":["PMC11905962"],"funding_grant_id":["UL1 TR002243","R01 MH123804","U01 HG004798","RC2 GM092618","U01 HG006378","UL1 TR000445","T32 GM007347","K08 MH122911","R01 NS032830","R01 MH116269","R01 AG067025","R01 MH116270","P50 GM115305","UL1 RR024975","I01 BX002395","I01 BX004189","R01 MH109677","R01 MH121455","S10 RR025141","R01 HD074711","U01 MH116442","R01 MH125246","K99 MH127366","U19 HL065962"],"pubmed_authors":["Roussos P","Hu Y","Han L","Castro VM","Venkatesh S","Chabris C","Wilimitis D","Kim RY","Heckers S","Ripperger M","Ge T","Voloudakis G","Burstein D","Rocha DB","McCoy TH","Ruderfer DM","Perlis RH","Feng YA","Kang J","Morley T","Linner RK","Walsh CG"],"additional_accession":[]},"is_claimable":false,"name":"Genome-Wide Association Study of Treatment-Resistant Depression: Shared Biology With Metabolic Traits.","description":"<h4>Objective</h4>Treatment-resistant depression (TRD) occurs in roughly one-third of all individuals with major depressive disorder (MDD). Although research has suggested a significant common variant genetic component of liability to TRD, with heritability estimated at 8% when compared with non-treatment-resistant MDD, no replicated genetic loci have been identified, and the genetic architecture of TRD remains unclear. A key barrier to this work has been the paucity of adequately powered cohorts for investigation, largely because of the challenge in prospectively investigating this phenotype. The objective of this study was to perform a well-powered genetic study of TRD.<h4>Methods</h4>Using receipt of electroconvulsive therapy (ECT) as a surrogate for TRD, the authors applied standard ma","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-01T16:01:27.606Z","creation":"2026-04-08T14:03:25.655Z"},"accession":"S-EPMC11905962","cross_references":{"pubmed":["38745458"],"doi":["10.1176/appi.ajp.20230247"]}}