biostudies-literatureUnknown15(1)Mo JWe retrospectively analyzed the degree of stenosis in patients with acute cerebral infarction (CI) to investigate the correlation between C-reactive protein (CRP)/ albumin ratio and intracranial atherosclerotic stenosis (ICAS). Meanwhile, the differentially expressed genes (DEGs) in CI were identified through two Microarray profile GSE202518 and GSE180470. The receiver operating characteristics (ROC) curve analysis were performed to evaluate the sensitivity and specificity of CRP/ albumin ratio for the diagnosis of ICAS. Binary logistic regression models were used to examine the relationship between these biomarkers and the degree of ICAS, adjusting for potential confounders. The level of CRP/ albumin ratio in high group was significantly higher than that in low group. The area under the cScientific reports8653https://www.ebi.ac.uk/biostudies/studies/S-EPMC11906579biostudies-literatureDiagnostic value of C-reactive protein/ albumin ratio and TMTC1 in intracranial atherosclerotic stenosis in patients with acute cerebral infarction.PMC11906579Li ZLong GLiu LHu ZTan YMo JfalseDiagnostic value of C-reactive protein/ albumin ratio and TMTC1 in intracranial atherosclerotic stenosis in patients with acute cerebral infarction.We retrospectively analyzed the degree of stenosis in patients with acute cerebral infarction (CI) to investigate the correlation between C-reactive protein (CRP)/ albumin ratio and intracranial atherosclerotic stenosis (ICAS). Meanwhile, the differentially expressed genes (DEGs) in CI were identified through two Microarray profile GSE202518 and GSE180470. The receiver operating characteristics (ROC) curve analysis were performed to evaluate the sensitivity and specificity of CRP/ albumin ratio for the diagnosis of ICAS. Binary logistic regression models were used to examine the relationship between these biomarkers and the degree of ICAS, adjusting for potential confounders. The level of CRP/ albumin ratio in high group was significantly higher than that in low group. The area under the c2025-01-01T00:00:00Z2025 Mar2026-07-15T05:43:28.714Z2025-04-03T23:23:42.535ZS-EPMC119065794008262610.1038/s41598-025-92714-1