{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Guan Q"],"pubmed_abstract":["<h4>Introduction</h4>Pyroptosis is an important inflammatory form of cell death and <i>Mycobacterium tuberculosis</i> (<i>M.tb</i>) chronic infection triggers excessive inflammatory pyroptosis of macrophages. Our previous research has confirmed that a small compound pyrvinium pamoate (PP) could inhibit inflammatory pathological changes and mycobacterial burden in <i>M.tb</i>-infected mice, but the potential mechanism of PP for inhibiting <i>M.tb</i>-induced inflammation remains unexplored.<h4>Methods</h4>The effects of PP on the NLRP3-ASC-Casp1 inflammasome assembly and activation, gasdermin D (GSDMD) mediated pyroptosis and inflammatory cytokines expression were assessed in human THP-1-derived macrophages after <i>M.tb</i> H37Rv/H37Ra/ <i>Salmonella typhimurium</i> (<i>S. typhimurium</i>)"],"journal":["Frontiers in immunology"],"pagination":["1553093"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11906677"],"repository":["biostudies-literature"],"pubmed_title":["Suppression of NLRP3 inflammasome by a small molecule targeting CK1α-β-catenin-NF-κB and CK1α-NRF2-mitochondrial OXPHOS pathways during mycobacterial infection."],"pmcid":["PMC11906677"],"pubmed_authors":["Xie Y","Nie Q","Guan Q","Liu S","Song X","Zhang XL","Guang Y","Xiong H"],"additional_accession":[]},"is_claimable":false,"name":"Suppression of NLRP3 inflammasome by a small molecule targeting CK1α-β-catenin-NF-κB and CK1α-NRF2-mitochondrial OXPHOS pathways during mycobacterial infection.","description":"<h4>Introduction</h4>Pyroptosis is an important inflammatory form of cell death and <i>Mycobacterium tuberculosis</i> (<i>M.tb</i>) chronic infection triggers excessive inflammatory pyroptosis of macrophages. Our previous research has confirmed that a small compound pyrvinium pamoate (PP) could inhibit inflammatory pathological changes and mycobacterial burden in <i>M.tb</i>-infected mice, but the potential mechanism of PP for inhibiting <i>M.tb</i>-induced inflammation remains unexplored.<h4>Methods</h4>The effects of PP on the NLRP3-ASC-Casp1 inflammasome assembly and activation, gasdermin D (GSDMD) mediated pyroptosis and inflammatory cytokines expression were assessed in human THP-1-derived macrophages after <i>M.tb</i> H37Rv/H37Ra/ <i>Salmonella typhimurium</i> (<i>S. typhimurium</i>)","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-04-20T00:08:06.737Z","creation":"2025-04-20T00:08:06.737Z"},"accession":"S-EPMC11906677","cross_references":{"pubmed":["40092991"],"doi":["10.3389/fimmu.2025.1553093"]}}