{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["Pan ZJ"],"pubmed_abstract":["Helper-component proteinase (HC-Pro), encoded by potyviruses, function as viral suppressors of RNA silencing (VSRs). Despite their conserved role, HC-Pros share approximately 40% similarity, implying potential differences in VSR efficiency, particularly in their ability to inhibit HEN1 methyltransferase activity. This study investigated the inhibitory potential of HC-Pros from different potyviruses in transgenic plants. P1/HC-Pro from turnip mosaic virus (P1/HC-Pro<sup>Tu</sup>) exhibited the most potent inhibition of HEN1, followed by P1/HC-Pro from zucchini yellow mosaic virus (P1/HC-Pro<sup>Zy</sup>), while P1/HC-Pro from tobacco etch virus (P1/HC-Pro<sup>Te</sup>) showed the weakest inhibitory effect. These differential effectual effects corresponded to variations in unmethylated micro"],"journal":["Nature communications"],"pagination":["2503"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11906750"],"repository":["biostudies-literature"],"pubmed_title":["HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1."],"pmcid":["PMC11906750"],"pubmed_authors":["Cheng CH","Pham TH","Fang RY","Bowman JL","Shen TL","Lin SS","Jane WN","Yang JT","Lin PC","Hung YL","Hu SF","Wu HY","Shang QW","Wei WL","Shen BN","Chang HH","Chung CT","Lin CS","Tran PA","Hong SF","Wu FH","Wang CC","Pan ZJ"],"additional_accession":[]},"is_claimable":false,"name":"HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1.","description":"Helper-component proteinase (HC-Pro), encoded by potyviruses, function as viral suppressors of RNA silencing (VSRs). Despite their conserved role, HC-Pros share approximately 40% similarity, implying potential differences in VSR efficiency, particularly in their ability to inhibit HEN1 methyltransferase activity. This study investigated the inhibitory potential of HC-Pros from different potyviruses in transgenic plants. P1/HC-Pro from turnip mosaic virus (P1/HC-Pro<sup>Tu</sup>) exhibited the most potent inhibition of HEN1, followed by P1/HC-Pro from zucchini yellow mosaic virus (P1/HC-Pro<sup>Zy</sup>), while P1/HC-Pro from tobacco etch virus (P1/HC-Pro<sup>Te</sup>) showed the weakest inhibitory effect. These differential effectual effects corresponded to variations in unmethylated micro","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-03-18T13:20:29.793Z","creation":"2025-04-05T22:07:42.006Z"},"accession":"S-EPMC11906750","cross_references":{"pubmed":["40082396"],"doi":["10.1038/s41467-025-56320-z"]}}