{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Goto R"],"funding":["Japan Agency for Medical Research and Development"],"pagination":["8640"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11906790"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<sup>18</sup>F-SPAL-T-06 and <sup>18</sup>F-C05-05 are two novel positron emission tomography (PET) radioligands targeting α-synuclein fibrils. Our study aimed to evaluate the biodistribution, safety, and radiation dosimetry of each tracer in humans. Biodistribution and radiation dosimetry studies were carried out with two healthy volunteers for each tracer, <sup>18</sup>F-SPAL-T-06 (one female and one male volunteer, both aged 63 years) and <sup>18</sup>F-C05-05 (one female and one male volunteer, aged 63 and 73 years, respectively). After injection of either tracer, dynamic PET images were acquired from head to upper thigh. Effective dose of each tracer was estimated using OLINDA/EXM Version 2.2. Injection of either of the tracers caused no adverse effects. Greatest uptake of both tracer"],"journal":["Scientific reports"],"pubmed_title":["Human biodistribution and radiation dosimetry of two novel α-synuclein PET tracers, &lt;sup&gt;18&lt;/sup&gt;F-SPAL-T-06 and &lt;sup&gt;18&lt;/sup&gt;F-C05-05."],"pmcid":["PMC11906790"],"funding_grant_id":["JP24wm0625001","JP21wm0425015"],"pubmed_authors":["Matsuoka K","Kimura Y","Kawamura K","Higuchi M","Tagai K","Endo H","Zhang MR","Goto R","Hirata K","Seki C","Takahata K","Oya M","Kataoka Y"],"additional_accession":[]},"is_claimable":false,"name":"Human biodistribution and radiation dosimetry of two novel α-synuclein PET tracers, &lt;sup&gt;18&lt;/sup&gt;F-SPAL-T-06 and &lt;sup&gt;18&lt;/sup&gt;F-C05-05.","description":"<sup>18</sup>F-SPAL-T-06 and <sup>18</sup>F-C05-05 are two novel positron emission tomography (PET) radioligands targeting α-synuclein fibrils. Our study aimed to evaluate the biodistribution, safety, and radiation dosimetry of each tracer in humans. Biodistribution and radiation dosimetry studies were carried out with two healthy volunteers for each tracer, <sup>18</sup>F-SPAL-T-06 (one female and one male volunteer, both aged 63 years) and <sup>18</sup>F-C05-05 (one female and one male volunteer, aged 63 and 73 years, respectively). After injection of either tracer, dynamic PET images were acquired from head to upper thigh. Effective dose of each tracer was estimated using OLINDA/EXM Version 2.2. Injection of either of the tracers caused no adverse effects. Greatest uptake of both tracer","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-26T03:26:10.638Z","creation":"2025-04-06T10:46:58.224Z"},"accession":"S-EPMC11906790","cross_references":{"pubmed":["40082668"],"doi":["10.1038/s41598-025-93520-5"]}}