{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kuse Y"],"funding":["Ministry of Education, Culture, Sports, Science and Technology (MEXT)","Japan Agency for Medical Research and Development (AMED)"],"pagination":["2493"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11906828"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Organoids derived from human induced pluripotent stem cells (hiPSC) are potentially applicable for regenerative medicine. However, the applications have been hampered by limited organoid size and function as a consequence of a lack of progenitor expansion. Here, we report the recapitulation of progenitor expansion in hiPSC-liver organoids based on the analysis of mouse development. Visualization of blood perfusion and oxygen levels in mouse embryos reveals a transient hypoxic environment during hepatoblast expansion, despite active blood flow. During this specific stage, the placenta expresses various growth factors. Human and mouse placenta-liver interaction analysis identifies various placenta-derived factors. Among them, IL1α efficiently induces the growth in hiPSC-liver organoids as we"],"journal":["Nature communications"],"pubmed_title":["Placenta-derived factors contribute to human iPSC-liver organoid growth."],"pmcid":["PMC11906828"],"funding_grant_id":["19K18034","JP13bm0304002","22K16440","JP22bm0304002h0310","21H04830","JP23bm1223007"],"pubmed_authors":["Matsumoto S","Kasai T","Tsuzuki S","Ueno Y","Oba T","Kuse Y","Furukawa Y","Tadokoro T","Carolina E","Yamabe S","Taniguchi H","Tanimizu N","Yamaguchi K","Okumura T"],"additional_accession":[]},"is_claimable":false,"name":"Placenta-derived factors contribute to human iPSC-liver organoid growth.","description":"Organoids derived from human induced pluripotent stem cells (hiPSC) are potentially applicable for regenerative medicine. However, the applications have been hampered by limited organoid size and function as a consequence of a lack of progenitor expansion. Here, we report the recapitulation of progenitor expansion in hiPSC-liver organoids based on the analysis of mouse development. Visualization of blood perfusion and oxygen levels in mouse embryos reveals a transient hypoxic environment during hepatoblast expansion, despite active blood flow. During this specific stage, the placenta expresses various growth factors. Human and mouse placenta-liver interaction analysis identifies various placenta-derived factors. Among them, IL1α efficiently induces the growth in hiPSC-liver organoids as we","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-04-08T19:48:37.734Z","creation":"2025-04-05T22:08:05.308Z"},"accession":"S-EPMC11906828","cross_references":{"pubmed":["40082402"],"doi":["10.1038/s41467-025-57551-w"]}}