{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(2)"],"submitter":["Tremblay C"],"pubmed_abstract":["Alzheimer's disease is associated with pre-symptomatic changes in brain morphometry and accumulation of abnormal tau and amyloid-beta pathology. Studying the development of brain changes prior to symptoms onset may lead to early diagnostic biomarkers and a better understanding of Alzheimer's disease pathophysiology. Alzheimer's disease pathology is thought to arise from a combination of protein accumulation and spreading via neural connections, but how these processes influence brain atrophy progression in the pre-symptomatic phases remains unclear. Individuals with a family history of Alzheimer's disease (FHAD) have an elevated risk of Alzheimer's disease, providing an opportunity to study the pre-symptomatic phase. Here, we used structural MRI from three databases (Alzheimer's Disease Ne"],"journal":["Brain communications"],"pagination":["fcaf099"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11906971"],"repository":["biostudies-literature"],"pubmed_title":["Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease."],"pmcid":["PMC11906971"],"pubmed_authors":["Lafaille-Magnan ME","Poirier J","Rheault F","Aisen PS","Wan K","Hoge R","Montine T","Tremblay C","Fonov V","Vogel J","Munter LM","Fontaine D","Kat J","Labonte A","PREVENT-AD Research Group","Page V","Ituria-Medina Y","Peillieux S","Rioux P","Verfaillie S","Daneault V","Descoteaux M","Venugopalan V","Kazazian C","Ayranci G","Lalancette M","Teigner E","Yu E","Toga AW","Petkova M","Harvey DJ","Villeneuve S","Leoutsakos JM","Thomas R","Pascoal T","Gamst AC","Rajah N","Appleby M","Ferdinand F","Dadar M","Mayrand G","Jagust WJ","Rosa-Neto P","Lambert JC","Bohbot V","St-Onge F","Soucy JP","Sperling R","Collins DL","Dagher A","Bedetti C","Gagne G","Vachon-Presseau E","Tabrizi S","Saint-Fort EF","Multhaup G","Brandt J","Gauthier S","Toussaint PJ","Jack CR","Trojanowski JQ","Ashton N","Amouyel P","Vo A","Wang S","Morys F","Lepage C","Maltais JR","Evans A","Mathotaarachchi S","Michaud D","Dufour M","Petersen RC","Rahayel S","Donohue MC","Daoust LA","Beckett LA","Weiner MW","Cuello C","Bellec P","Tuwaig M","Farzin S","Das S","Chakravarty M","Etienne P","Maillet D","Dauar-Tedeschi M","Westman AB","De Beaumont L","Nair V","Madjar C","Sager M","Morris J","Alzheimer’s Disease Neuroimaging Initiative (ADNI)","Baillet S","Savard M","Dea D","Pastor-Bernier A","Breitner J","Tariot P","Shaw LM","Gonneaud J"],"additional_accession":[]},"is_claimable":false,"name":"Uncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease.","description":"Alzheimer's disease is associated with pre-symptomatic changes in brain morphometry and accumulation of abnormal tau and amyloid-beta pathology. Studying the development of brain changes prior to symptoms onset may lead to early diagnostic biomarkers and a better understanding of Alzheimer's disease pathophysiology. Alzheimer's disease pathology is thought to arise from a combination of protein accumulation and spreading via neural connections, but how these processes influence brain atrophy progression in the pre-symptomatic phases remains unclear. Individuals with a family history of Alzheimer's disease (FHAD) have an elevated risk of Alzheimer's disease, providing an opportunity to study the pre-symptomatic phase. Here, we used structural MRI from three databases (Alzheimer's Disease Ne","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-04-18T12:46:20.69Z","creation":"2025-04-06T22:09:37.289Z"},"accession":"S-EPMC11906971","cross_references":{"pubmed":["40092368"],"doi":["10.1093/braincomms/fcaf099"]}}