biostudies-literatureUnknown7(2)Tremblay CAlzheimer's disease is associated with pre-symptomatic changes in brain morphometry and accumulation of abnormal tau and amyloid-beta pathology. Studying the development of brain changes prior to symptoms onset may lead to early diagnostic biomarkers and a better understanding of Alzheimer's disease pathophysiology. Alzheimer's disease pathology is thought to arise from a combination of protein accumulation and spreading via neural connections, but how these processes influence brain atrophy progression in the pre-symptomatic phases remains unclear. Individuals with a family history of Alzheimer's disease (FHAD) have an elevated risk of Alzheimer's disease, providing an opportunity to study the pre-symptomatic phase. Here, we used structural MRI from three databases (Alzheimer's Disease NeBrain communicationsfcaf099https://www.ebi.ac.uk/biostudies/studies/S-EPMC11906971biostudies-literatureUncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease.PMC11906971Lafaille-Magnan MEPoirier JRheault FAisen PSWan KHoge RMontine TTremblay CFonov VVogel JMunter LMFontaine DKat JLabonte APREVENT-AD Research GroupPage VIturia-Medina YPeillieux SRioux PVerfaillie SDaneault VDescoteaux MVenugopalan VKazazian CAyranci GLalancette MTeigner EYu EToga AWPetkova MHarvey DJVilleneuve SLeoutsakos JMThomas RPascoal TGamst ACRajah NAppleby MFerdinand FDadar MMayrand GJagust WJRosa-Neto PLambert JCBohbot VSt-Onge FSoucy JPSperling RCollins DLDagher ABedetti CGagne GVachon-Presseau ETabrizi SSaint-Fort EFMulthaup GBrandt JGauthier SToussaint PJJack CRTrojanowski JQAshton NAmouyel PVo AWang SMorys FLepage CMaltais JREvans AMathotaarachchi SMichaud DDufour MPetersen RCRahayel SDonohue MCDaoust LABeckett LAWeiner MWCuello CBellec PTuwaig MFarzin SDas SChakravarty MEtienne PMaillet DDauar-Tedeschi MWestman ABDe Beaumont LNair VMadjar CSager MMorris JAlzheimer’s Disease Neuroimaging Initiative (ADNI)Baillet SSavard MDea DPastor-Bernier ABreitner JTariot PShaw LMGonneaud JfalseUncovering atrophy progression pattern and mechanisms in individuals at risk of Alzheimer's disease.Alzheimer's disease is associated with pre-symptomatic changes in brain morphometry and accumulation of abnormal tau and amyloid-beta pathology. Studying the development of brain changes prior to symptoms onset may lead to early diagnostic biomarkers and a better understanding of Alzheimer's disease pathophysiology. Alzheimer's disease pathology is thought to arise from a combination of protein accumulation and spreading via neural connections, but how these processes influence brain atrophy progression in the pre-symptomatic phases remains unclear. Individuals with a family history of Alzheimer's disease (FHAD) have an elevated risk of Alzheimer's disease, providing an opportunity to study the pre-symptomatic phase. Here, we used structural MRI from three databases (Alzheimer's Disease Ne2025-01-01T00:00:00Z20252025-04-18T12:46:20.69Z2025-04-06T22:09:37.289ZS-EPMC119069714009236810.1093/braincomms/fcaf099