{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bolis M"],"funding":["Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico"],"pagination":["359"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11907959"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["<h4>Background</h4>Prolonged SARS-CoV-2 infection observed in immunocompromised individuals even in the presence of antiviral treatment provides opportunities for viruses to evolve in immune escape and drug-resistant variants.<h4>Case presentation</h4>A 72-year-old male with IgG4-related disease was admitted to the Emergency Department of a city Hospital in Milan and then transferred to Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico in December 2023, due to respiratory distress due to SARS-CoV-2 infection diagnosed in November 2023. After 117 days since the onset of the infection, and two cycles of sotrovimab/remdesivir combined therapy, the clinical improvement allowed the hospital discharge, notwithstanding the persistent SARS-CoV-2 positivity. Fifteen days later, the patient "],"journal":["BMC infectious diseases"],"pubmed_title":["SARS-CoV-2 genomic evolution during a severe and long-lasting omicron infection under antiviral therapy."],"pmcid":["PMC11907959"],"funding_grant_id":["STOP-COVID"],"pubmed_authors":["Pastena A","Alagna L","Alteri C","Uceda Renteria S","Muscatello A","Liparoti A","Passerini BZ","Bandera A","Bolis M","Callegaro A","Parisi A"],"additional_accession":[]},"is_claimable":false,"name":"SARS-CoV-2 genomic evolution during a severe and long-lasting omicron infection under antiviral therapy.","description":"<h4>Background</h4>Prolonged SARS-CoV-2 infection observed in immunocompromised individuals even in the presence of antiviral treatment provides opportunities for viruses to evolve in immune escape and drug-resistant variants.<h4>Case presentation</h4>A 72-year-old male with IgG4-related disease was admitted to the Emergency Department of a city Hospital in Milan and then transferred to Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico in December 2023, due to respiratory distress due to SARS-CoV-2 infection diagnosed in November 2023. After 117 days since the onset of the infection, and two cycles of sotrovimab/remdesivir combined therapy, the clinical improvement allowed the hospital discharge, notwithstanding the persistent SARS-CoV-2 positivity. Fifteen days later, the patient ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-04T14:47:59.864Z","creation":"2025-04-04T14:47:59.864Z"},"accession":"S-EPMC11907959","cross_references":{"pubmed":["40082784"],"doi":["10.1186/s12879-025-10740-w"]}}