{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(1)"],"submitter":["Hyeon DY"],"pubmed_abstract":["We report proteogenomic analysis of locally advanced cervical cancer (LACC). Exome-seq data revealed predominant alterations of keratinization-TP53 regulation and O-glycosylation-TP53 regulation axes in squamous and adeno-LACC, respectively, compared to in early-stage cervical cancer. Integrated clustering of mRNA, protein, and phosphorylation data identified six subtypes (Sub1-6) of LACC among which Sub3, 5, and 6 showed the treatment-resistant nature with poor local recurrence-free survival. Elevated immune and extracellular matrix (ECM) activation mediated by activated stroma (PDGFD and CXCL1<sup>high</sup> fibroblasts) characterized the immune-hot Sub3 enriched with MUC5AC<sup>high</sup> epithelial cells (ECs). Increased epithelial-mesenchymal-transition (EMT) and ECM remodeling charac"],"journal":["Molecular cancer"],"pagination":["77"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11908047"],"repository":["biostudies-literature"],"pubmed_title":["Proteogenomic characterization of molecular and cellular targets for treatment-resistant subtypes in locally advanced cervical cancers."],"pmcid":["PMC11908047"],"pubmed_authors":["Kim SS","Kim H","Ku JL","Hong EK","Park KS","Choi W","Yoo CW","Kim JY","Kang C","Madar IH","Baek HJ","Kang J","Shin DH","Kim SJ","Shin Y","Shin HJ","Bae J","Back S","Jeong J","Jung E","Lee SJ","Jung K","Nam D","Kim JK","Bae YK","Hyeon DY","Lim MC","Kim DK","Kim S","Hwang D","Park GW","Lee SW","Cho SY"],"additional_accession":[]},"is_claimable":false,"name":"Proteogenomic characterization of molecular and cellular targets for treatment-resistant subtypes in locally advanced cervical cancers.","description":"We report proteogenomic analysis of locally advanced cervical cancer (LACC). Exome-seq data revealed predominant alterations of keratinization-TP53 regulation and O-glycosylation-TP53 regulation axes in squamous and adeno-LACC, respectively, compared to in early-stage cervical cancer. Integrated clustering of mRNA, protein, and phosphorylation data identified six subtypes (Sub1-6) of LACC among which Sub3, 5, and 6 showed the treatment-resistant nature with poor local recurrence-free survival. Elevated immune and extracellular matrix (ECM) activation mediated by activated stroma (PDGFD and CXCL1<sup>high</sup> fibroblasts) characterized the immune-hot Sub3 enriched with MUC5AC<sup>high</sup> epithelial cells (ECs). Increased epithelial-mesenchymal-transition (EMT) and ECM remodeling charac","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-02T07:17:11.478Z","creation":"2025-04-05T12:39:00.238Z"},"accession":"S-EPMC11908047","cross_references":{"pubmed":["40087745"],"doi":["10.1186/s12943-025-02256-3"]}}