{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Roederer AL"],"funding":["NIDA NIH HHS","NIAID NIH HHS"],"pubmed_abstract":["Studies have demonstrated that repeated mRNA vaccination enhances the breadth of neutralization against diverse SARS-CoV-2 variants. However, the development of antibodies capable of neutralizing across the Coronavirinae subfamily is poorly understood. In this study, we analyze serum samples to determine their neutralization breadth and potency and identify their antigenic targets. Using a cohort of older individuals and healthcare workers, we track correlates of broad neutralizing responses, including fusion peptide (FP) antibody elicitation. We find that although broadly neutralizing responses are often a result of RBD-specific antibodies, a rare subset of donors produce FP-specific broadly neutralizing responses. Interestingly, FP-specific antibodies are not observed in COVID-naive indi"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2025.03.01.25323010"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11908342"],"repository":["biostudies-literature"],"pubmed_title":["SARS-CoV-2 Fusion Peptide-Directed Antibodies Elicited by Natural Infection Mediate Broad Sarbecovirus Neutralization."],"pmcid":["PMC11908342"],"funding_grant_id":["DP2 DA040254","R01 AI174875","R01 AI129709","R01 AI174276"],"pubmed_authors":["Roederer AL","Li CJ","Lim E","Cao Y","Gravenstein S","Balazs AB","Canaday DH"],"additional_accession":[]},"is_claimable":false,"name":"SARS-CoV-2 Fusion Peptide-Directed Antibodies Elicited by Natural Infection Mediate Broad Sarbecovirus Neutralization.","description":"Studies have demonstrated that repeated mRNA vaccination enhances the breadth of neutralization against diverse SARS-CoV-2 variants. However, the development of antibodies capable of neutralizing across the Coronavirinae subfamily is poorly understood. In this study, we analyze serum samples to determine their neutralization breadth and potency and identify their antigenic targets. Using a cohort of older individuals and healthcare workers, we track correlates of broad neutralizing responses, including fusion peptide (FP) antibody elicitation. We find that although broadly neutralizing responses are often a result of RBD-specific antibodies, a rare subset of donors produce FP-specific broadly neutralizing responses. Interestingly, FP-specific antibodies are not observed in COVID-naive indi","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-04-08T19:31:11.392Z","creation":"2025-04-06T11:40:38.328Z"},"accession":"S-EPMC11908342","cross_references":{"pubmed":["40093263"],"doi":["10.1101/2025.03.01.25323010"]}}