{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27"],"submitter":["Yu Z"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["Tandem repeat sequences (TRs), a class of repetitive genomic elements, are broadly distributed in both coding and non-coding regions. Investigating the relationship between sequences and function is essential for understanding the genome. <i>Saccharomyces cerevisiae</i> serves as a vital model organism and is widely used as an engineered strain. Although the transcriptional regulatory functions of TRs in the promoters of <i>S.cerevisiae</i> have been elucidated, our understanding of their roles within coding sequences (CDS) remains limited. In this study, we integrate RNA-seq, ChIP-seq, ATAC-seq, Hi-C, and Micro-C data from <i>S.cerevisiae</i> to analyze the types and distribution of TRs, and their impact on gene expression. Our results indicate that genes containing short tandem repeats ("],"journal":["Computational and structural biotechnology journal"],"pagination":["705-716"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11908461"],"repository":["biostudies-literature"],"pubmed_title":["Identifying associations between short tandem repeat sequences and gene expression in yeast reveals specific repeated motifs encoding transcriptional regulatory proteins."],"pmcid":["PMC11908461"],"pubmed_authors":["Xu K","Ran D","Liang Y","Luo Y","Bo X","Chen H","Yu Z","Xu X","Xiang M","Chen B"],"additional_accession":[]},"is_claimable":false,"name":"Identifying associations between short tandem repeat sequences and gene expression in yeast reveals specific repeated motifs encoding transcriptional regulatory proteins.","description":"Tandem repeat sequences (TRs), a class of repetitive genomic elements, are broadly distributed in both coding and non-coding regions. Investigating the relationship between sequences and function is essential for understanding the genome. <i>Saccharomyces cerevisiae</i> serves as a vital model organism and is widely used as an engineered strain. Although the transcriptional regulatory functions of TRs in the promoters of <i>S.cerevisiae</i> have been elucidated, our understanding of their roles within coding sequences (CDS) remains limited. In this study, we integrate RNA-seq, ChIP-seq, ATAC-seq, Hi-C, and Micro-C data from <i>S.cerevisiae</i> to analyze the types and distribution of TRs, and their impact on gene expression. Our results indicate that genes containing short tandem repeats (","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-01T06:07:10.023Z","creation":"2025-04-06T22:09:56.684Z"},"accession":"S-EPMC11908461","cross_references":{"pubmed":["40092660"],"doi":["10.1016/j.csbj.2025.02.003"]}}