{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Clarke GS"],"funding":["Australian Government Research Training Program Stipend Scholarship","DHAC | National Health and Medical Research Council (NHMRC)"],"pagination":["1461-1481"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11908482"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["603(6)"],"pubmed_abstract":["Gastric vagal afferents (GVAs) sense food-related mechanical stimuli and signal to the CNS to initiate meal termination. Pregnancy and diet-induced obesity are independently associated with dampened GVA mechanosensitivity and increased food intake. Whether a high-fat, high-sugar diet (HFHSD) impacts pregnancy-related adaptations in GVA signalling is unknown and was investigated in this study. Three-week-old female Glu Venus-expressing mice, on a C57BL/6 background, were fed standard laboratory diet (SLD) or HFHSD for 12 weeks, and then half of each group were mated to generate late pregnant (Day 17.5; P-SLD N = 12, P-HFHSD N = 14) or non-pregnant (NP-SLD N = 12, NP-HFHSD N = 16) groups. Body weight and food intake were monitored in Promethion metabolic cages from before mating until Day 17"],"journal":["The Journal of physiology"],"pubmed_title":["Pregnancy and a high-fat, high-sugar diet each attenuate mechanosensitivity of murine gastric vagal afferents, with no additive effects."],"pmcid":["PMC11908482"],"funding_grant_id":["GNT1092158"],"pubmed_authors":["Li H","Gatford KL","Heshmati E","Clarke GS","Page AJ","Nicholas LM"],"additional_accession":[]},"is_claimable":false,"name":"Pregnancy and a high-fat, high-sugar diet each attenuate mechanosensitivity of murine gastric vagal afferents, with no additive effects.","description":"Gastric vagal afferents (GVAs) sense food-related mechanical stimuli and signal to the CNS to initiate meal termination. Pregnancy and diet-induced obesity are independently associated with dampened GVA mechanosensitivity and increased food intake. Whether a high-fat, high-sugar diet (HFHSD) impacts pregnancy-related adaptations in GVA signalling is unknown and was investigated in this study. Three-week-old female Glu Venus-expressing mice, on a C57BL/6 background, were fed standard laboratory diet (SLD) or HFHSD for 12 weeks, and then half of each group were mated to generate late pregnant (Day 17.5; P-SLD N = 12, P-HFHSD N = 14) or non-pregnant (NP-SLD N = 12, NP-HFHSD N = 16) groups. Body weight and food intake were monitored in Promethion metabolic cages from before mating until Day 17","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-26T03:30:25.202Z","creation":"2025-04-06T10:47:51.079Z"},"accession":"S-EPMC11908482","cross_references":{"pubmed":["40023799"],"doi":["10.1113/JP286115"]}}