biostudies-literatureFritze SGerman Research FoundationH. Lundbeck GmbH556-570https://www.ebi.ac.uk/biostudies/studies/S-EPMC11908873biostudies-literatureUnknown51(2)<h4>Background and hypothesis</h4>Parkinsonism, psychomotor slowing, negative and depressive symptoms show evident phenomenological similarities across different mental disorders. However, the extent to which they interact with each other is currently unclear. Here, we hypothesized that parkinsonism is an independent motor abnormality showing limited associations with psychomotor slowing, negative and depressive symptoms in schizophrenia spectrum (SSD), and mood disorders (MOD).<h4>Study design</h4>We applied network analysis and community detection methods to examine the interplay and centrality (expected influence [EI] and strength) between parkinsonism, psychomotor slowing, negative and depressive symptoms in 245 SSD and 99 MOD patients. Parkinsonism was assessed with the Simpson-Angus Schizophrenia bulletinParkinsonism, Psychomotor Slowing, Negative and Depressive Symptoms in Schizophrenia Spectrum and Mood Disorders: Exploring Their Intricate Nexus Using a Network Analytic Approach.PMC11908873HI 1928/6-1HI 1928/5-1HI 1928/2-1Benedyk ADaub JKubera KMKukovic JSchwarz EKrayem MHirjak DTost HBraun UVolkmer SFritze SMoldavski AWolf RCNorthoff GMeyer-Lindenberg ABrandt GAfalseParkinsonism, Psychomotor Slowing, Negative and Depressive Symptoms in Schizophrenia Spectrum and Mood Disorders: Exploring Their Intricate Nexus Using a Network Analytic Approach.<h4>Background and hypothesis</h4>Parkinsonism, psychomotor slowing, negative and depressive symptoms show evident phenomenological similarities across different mental disorders. However, the extent to which they interact with each other is currently unclear. Here, we hypothesized that parkinsonism is an independent motor abnormality showing limited associations with psychomotor slowing, negative and depressive symptoms in schizophrenia spectrum (SSD), and mood disorders (MOD).<h4>Study design</h4>We applied network analysis and community detection methods to examine the interplay and centrality (expected influence [EI] and strength) between parkinsonism, psychomotor slowing, negative and depressive symptoms in 245 SSD and 99 MOD patients. Parkinsonism was assessed with the Simpson-Angus 2025-01-01T00:00:00Z2025 Mar2025-07-10T03:08:49.875Z2025-07-10T03:08:49.875ZS-EPMC119088733866509710.1093/schbul/sbae055