{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["45(1)"],"submitter":["Steinberg J"],"funding":["Universitätsklinikum Hamburg-Eppendorf (UKE)"],"pubmed_abstract":["<h4>Purpose</h4>This study aims to analyze the vision-related quality of life (vr-QoL) in keratoconus (KC) patients after corneal crosslinking (CXL).<h4>Methods</h4>A prospective clinical study was conducted, wherein 41 patients underwent assessment using the \"National Eye Institute Visual Functioning Questionnaire\" (NEI-25) and the \"Keratoconus Outcomes Research Questionnaire\" (KORQ) to evaluate vr-QoL, along with the examination of morphology and functional parameters before CXL, and at three and six months post-treatment. Rasch analyses were used to verify the measurement precision of the KORQ with our study population.<h4>Results</h4>There were no statistically significant changes observed in corneal morphology and best corrected visual acuity after CXL. Analysis of the NEI-25 questionnaires and KORQ demonstrated no statistically significant changes throughout the follow-up period. Rasch analyses revealed a high measurement precision of the KORQ within our population.<h4>Conclusion</h4>The study indicates that patients with progressive KC maintain stable vr-QoL after undergoing CXL. Based on our findings, we suggest considering very early CXL treatment for KC patients that are at high risk of progression."],"journal":["International ophthalmology"],"pagination":["103"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11909072"],"repository":["biostudies-literature"],"pubmed_title":["Quality of life in patients with progressive keratoconus treated with corneal collagen crosslinking."],"pmcid":["PMC11909072"],"pubmed_authors":["Linke SJ","Fischer P","Katz T","Druchkiv V","Frings A","Steinberg J"],"additional_accession":[]},"is_claimable":false,"name":"Quality of life in patients with progressive keratoconus treated with corneal collagen crosslinking.","description":"<h4>Purpose</h4>This study aims to analyze the vision-related quality of life (vr-QoL) in keratoconus (KC) patients after corneal crosslinking (CXL).<h4>Methods</h4>A prospective clinical study was conducted, wherein 41 patients underwent assessment using the \"National Eye Institute Visual Functioning Questionnaire\" (NEI-25) and the \"Keratoconus Outcomes Research Questionnaire\" (KORQ) to evaluate vr-QoL, along with the examination of morphology and functional parameters before CXL, and at three and six months post-treatment. Rasch analyses were used to verify the measurement precision of the KORQ with our study population.<h4>Results</h4>There were no statistically significant changes observed in corneal morphology and best corrected visual acuity after CXL. Analysis of the NEI-25 questionnaires and KORQ demonstrated no statistically significant changes throughout the follow-up period. Rasch analyses revealed a high measurement precision of the KORQ within our population.<h4>Conclusion</h4>The study indicates that patients with progressive KC maintain stable vr-QoL after undergoing CXL. Based on our findings, we suggest considering very early CXL treatment for KC patients that are at high risk of progression.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-12T03:14:39.676Z","creation":"2025-04-06T10:50:55.591Z"},"accession":"S-EPMC11909072","cross_references":{"pubmed":["40085326"],"doi":["10.1007/s10792-024-03400-6"]}}