{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou B"],"funding":["the Science and Technology Research Program of Chongqing Municipal Education Commission"],"pagination":["8869"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11909175"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, characterized by a high rate of postoperative recurrence and poor long-term survival outcomes. Structural maintenance of chromosome 4 (SMC4) is frequently overexpressed in various types of cancer and plays a pivotal role in tumor cell growth, migration, and invasion. Bioinformatics analysis has revealed a significant correlation between the tumor-node metastasis (TNM) stage (P < 0.01) and SMC4 expression (P < 0.05), and SMC4 was associated with poor prognosis in HCC. Furthermore, SMC4 was identified as an independent prognostic factor for HCC. Ubiquitin-specific peptidase 39 (USP39) was found whether the regulation was observed to affect protein synthesis or stability through bioinformatics analysis and immunopr"],"journal":["Scientific reports"],"pubmed_title":["USP39/SMC4 promotes hepatoma cell proliferation and 5-FU resistance."],"pmcid":["PMC11909175"],"funding_grant_id":["KJZD-K202412801"],"pubmed_authors":["Li J","Chen J","Zhou B","Zhang H","Wu S","Chen G","Luo Y"],"additional_accession":[]},"is_claimable":false,"name":"USP39/SMC4 promotes hepatoma cell proliferation and 5-FU resistance.","description":"Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, characterized by a high rate of postoperative recurrence and poor long-term survival outcomes. Structural maintenance of chromosome 4 (SMC4) is frequently overexpressed in various types of cancer and plays a pivotal role in tumor cell growth, migration, and invasion. Bioinformatics analysis has revealed a significant correlation between the tumor-node metastasis (TNM) stage (P < 0.01) and SMC4 expression (P < 0.05), and SMC4 was associated with poor prognosis in HCC. Furthermore, SMC4 was identified as an independent prognostic factor for HCC. Ubiquitin-specific peptidase 39 (USP39) was found whether the regulation was observed to affect protein synthesis or stability through bioinformatics analysis and immunopr","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-03T02:32:38.066Z","creation":"2025-04-04T00:32:37.518Z"},"accession":"S-EPMC11909175","cross_references":{"pubmed":["40087331"],"doi":["10.1038/s41598-025-93029-x"]}}