{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qian Q"],"funding":["Scientific Research Projects of Medical and Health Institutions of Longhua District, Shenzhen","Shenzhen Science and Technology Program"],"pagination":["64"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11909235"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["Ischemic stroke (IS), a leading cause of global disability and mortality, is characterized by white matter damage and demyelination. Despite advances, the molecular mechanisms driving post-IS myelin pathology remain poorly understood, limiting therapeutic development. This study investigates key myelin-related genes (MRGs) and their regulatory networks to identify novel therapeutic targets. A transient middle cerebral artery occlusion (MCAO) model was established in C57BL/6 mice, with brain tissues collected at four timepoints (Sham0D, MCAO0D, MCAO7D, MCAO14D). Transcriptomic and proteomic sequencing were performed, followed by soft clustering (Mfuzz), functional enrichment (GO/KEGG), and ROC analysis to identify key MRGs. Competing endogenous RNA (ceRNA) networks were constructed, and dru"],"journal":["Functional & integrative genomics"],"pubmed_title":["Combined transcriptomic and proteomic analyses reveal relevant myelin features in mice with ischemic stroke."],"pmcid":["PMC11909235"],"funding_grant_id":["2022073","RCBS20210609104401012","JCYJ20220530165207017"],"pubmed_authors":["Liu X","Shen M","Wang Q","He Y","Li D","Lyu H","Wang W","Qian Q"],"additional_accession":[]},"is_claimable":false,"name":"Combined transcriptomic and proteomic analyses reveal relevant myelin features in mice with ischemic stroke.","description":"Ischemic stroke (IS), a leading cause of global disability and mortality, is characterized by white matter damage and demyelination. Despite advances, the molecular mechanisms driving post-IS myelin pathology remain poorly understood, limiting therapeutic development. This study investigates key myelin-related genes (MRGs) and their regulatory networks to identify novel therapeutic targets. A transient middle cerebral artery occlusion (MCAO) model was established in C57BL/6 mice, with brain tissues collected at four timepoints (Sham0D, MCAO0D, MCAO7D, MCAO14D). Transcriptomic and proteomic sequencing were performed, followed by soft clustering (Mfuzz), functional enrichment (GO/KEGG), and ROC analysis to identify key MRGs. Competing endogenous RNA (ceRNA) networks were constructed, and dru","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-14T03:09:50.818Z","creation":"2025-04-20T00:09:53.536Z"},"accession":"S-EPMC11909235","cross_references":{"pubmed":["40085348"],"doi":["10.1007/s10142-025-01573-6"]}}