biostudies-literatureUnknown10Theuriet J<h4>Objective</h4>This study aimed to compare the frequency of blink reflex's contralateral R1 responses (R1') between patients with amyotrophic lateral sclerosis (ALS), non-ALS motor deficit patients, and healthy volunteers.<h4>Methods</h4>A total of 120 participants were prospectively recruited: 40 with ALS, 40 with a non-ALS motor deficit, and 40 healthy volunteers. Blink reflexes were recorded from orbicularis oculi muscles following supraorbital nerve stimulation.<h4>Results</h4>R1' was more frequent in the ALS group (42.5 %) compared to healthy volunteers (12.5 %, p = 0.00588), and compared to non-ALS patients (7.5 %, p = 0.000789). Bilateral R1' was observed only in ALS patients (22.5 %). No clinically significant difference was found in the latencies or amplitudes of the R1, R2, orClinical neurophysiology practice47-51https://www.ebi.ac.uk/biostudies/studies/S-EPMC11909417biostudies-literatureContralateral R1 response in blink reflex in patients with amyotrophic lateral sclerosis.PMC11909417Theuriet JMeens LDemia MPegat ASvahn JVallet AEAlves LRoux LMoussy MBarsan ICDion MJomir LCluse FBohic ABonjour MBouhour FBernard EPereon YfalseContralateral R1 response in blink reflex in patients with amyotrophic lateral sclerosis.<h4>Objective</h4>This study aimed to compare the frequency of blink reflex's contralateral R1 responses (R1') between patients with amyotrophic lateral sclerosis (ALS), non-ALS motor deficit patients, and healthy volunteers.<h4>Methods</h4>A total of 120 participants were prospectively recruited: 40 with ALS, 40 with a non-ALS motor deficit, and 40 healthy volunteers. Blink reflexes were recorded from orbicularis oculi muscles following supraorbital nerve stimulation.<h4>Results</h4>R1' was more frequent in the ALS group (42.5 %) compared to healthy volunteers (12.5 %, p = 0.00588), and compared to non-ALS patients (7.5 %, p = 0.000789). Bilateral R1' was observed only in ALS patients (22.5 %). No clinically significant difference was found in the latencies or amplitudes of the R1, R2, or2025-01-01T00:00:00Z20252026-05-26T14:00:20.608Z2025-04-06T11:37:46.12ZS-EPMC119094174009249610.1016/j.cnp.2025.02.005