biostudies-literatureUnknown45(4)Ramier C<h4>Background and aims</h4>Early assessment of hepatocellular carcinoma (HCC) risk could improve long-term outcomes in people with chronic hepatitis B virus (HBV) infection. Some existing HCC predictive scores are not easily implementable. We developed easy-to-use HCC predictive scores based on behavioural and routine bio-clinical data in people with chronic HBV infection.<h4>Methods</h4>Eight-year follow-up data was analysed from people with chronic HBV infection enrolled in the French ANRS CO22 HEPATHER cohort. Patients were randomly split into two samples (training/testing). A multivariable Cox model for time to HCC was estimated on the training sample. The HCC predictive score was computed by summing the points assigned to model predictors, normalising their coefficients over a 10-yeaLiver international : official journal of the International Association for the Study of the Livere70065https://www.ebi.ac.uk/biostudies/studies/S-EPMC11909585biostudies-literatureBehaviour-Based Predictive Scores of Hepatocellular Carcinoma in People With Chronic Hepatitis B (ANRS CO22 HEPATHER).PMC11909585Dharancy SPoumaroux BParlati LSubic MWampach ABuchard BBoursier JDelarocque-Astagneau EGoria OBrener ADorival CAsselah TAhmed SNSAmzal RGiuily NConroy GHermabessiere PAngoulevant BLafrance MJPetrov-Sanchez VCagnot CFontaine HPascale AParis FMouillot TMuti LBrigitte CDebette-Gratien Mde Ledinghen VDi Martino VTruchi RZoulim FRiffault RLeroy VScoazec GHammeche SCamou OHabersetzer FLe Meut GFoucher JHiriart JBLefebvre MSimoes MPageaux GPCarrier PCatherine LAndreani TANRS/AFEF CO22 HEPATHER Study GroupLunel FAndre-Garnier EPeron JMd'Asnieres de Salins AGPannetier GLassailly GDe Dieuleveult BBrusset BBonnet DGelu-Simeon MCostes LNicol JRoumy VMeszaros MNahon POules VBaumert TFSobesky RLerosey LChau FFourati SCarrieri PTran ADecaens TAnty RArchambeaud ICanivet CMaynard MRamier CLoustaud-Ratti VCostentin CMontialoux HRousseaud EGelsi EBronowicki JPBonadona ABourliere MAmaddeo GMoussali JBrule SVallee JDGanne NBoston AJaillais AChevalier CChane-Teng JBensenane-Oussalah MCoilly ABolle AGerster THadj-Rhouma SL'hennaff MHubert ILouvet AAbdesselam ZBMorales TRiachi GDiallo AMetivier SLusivika-Nzinga CBoutoille DDaude SJezequel CD'Alteroche LLabarriere DZucman-Rossi JMoins CBarrault CBailly FLatournerie MBureau CRaffi FThabut DDel Pozo LKibeche RLandry EPol SRoulot DHaghnejad VGoderel IMarcellin FSerfaty LVallet-Pichard ADi Beo VVaraut AAbergel ADao TGournay JBrouard CGrando-Lemaire VRolle VHilleret MNLarrue HBoyer NChazouillieres OProtopopescu CCanva VNicolas COuzan DGeist CLemaitre EMinello AElkrief LSizorn MCales PSimo-Noumbissie PRosa ICastelnau CMathurin PReymond MCarrat FOuarani BJeulin MBellet JAlric LBillaud EIrles-Depe MSogni PLarrey DSilvain CCausse XHousset CWittkop LFleurent CPortal IfalseBehaviour-Based Predictive Scores of Hepatocellular Carcinoma in People With Chronic Hepatitis B (ANRS CO22 HEPATHER).<h4>Background and aims</h4>Early assessment of hepatocellular carcinoma (HCC) risk could improve long-term outcomes in people with chronic hepatitis B virus (HBV) infection. Some existing HCC predictive scores are not easily implementable. We developed easy-to-use HCC predictive scores based on behavioural and routine bio-clinical data in people with chronic HBV infection.<h4>Methods</h4>Eight-year follow-up data was analysed from people with chronic HBV infection enrolled in the French ANRS CO22 HEPATHER cohort. Patients were randomly split into two samples (training/testing). A multivariable Cox model for time to HCC was estimated on the training sample. The HCC predictive score was computed by summing the points assigned to model predictors, normalising their coefficients over a 10-yea2025-01-01T00:00:00Z2025 Apr2026-06-01T15:10:15.249Z2025-04-06T11:38:52.024ZS-EPMC119095854008792210.1111/liv.70065