{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(2)"],"submitter":["Liu Q"],"pubmed_abstract":["<h4>Background</h4>Breast cancer has become a severe threat to human health, making it imperative to identify effective drugs and therapeutic targets.<h4>Methods</h4>Various molecular biology experiments, such as western blot analysis, cytologic effect, co-immunoprecipitation, and immunofluorescence assays, as well as a nude mouse xenograft tumor model, were used to comprehensively analyze the impact of gamma-interferon-inducible lysosomal thiol reductase (GILT) on the malignant phenotype of breast cancer cells. This work was performed to examine GILT expression levels and explore the potential mechanism in breast cancer.<h4>Results</h4>GILT protein expression levels were significantly lower in breast cancer cells than in normal breast epithelial cells. Overexpressing GILT inhibited breast"],"journal":["Cancer innovation"],"pagination":["e161"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11909800"],"repository":["biostudies-literature"],"pubmed_title":["Investigating the Mechanism of IFN-γ-Inducible Lysosomal Thiol Reductase-Mediated Inhibition of Breast Cancer Cell Proliferation."],"pmcid":["PMC11909800"],"pubmed_authors":["Liu H","Li H","Shao Y","Guan X","Feng K","Zhang J","Chen L","Tian Y","Liu Q","Yuan X","Chu M","Wei L"],"additional_accession":[]},"is_claimable":false,"name":"Investigating the Mechanism of IFN-γ-Inducible Lysosomal Thiol Reductase-Mediated Inhibition of Breast Cancer Cell Proliferation.","description":"<h4>Background</h4>Breast cancer has become a severe threat to human health, making it imperative to identify effective drugs and therapeutic targets.<h4>Methods</h4>Various molecular biology experiments, such as western blot analysis, cytologic effect, co-immunoprecipitation, and immunofluorescence assays, as well as a nude mouse xenograft tumor model, were used to comprehensively analyze the impact of gamma-interferon-inducible lysosomal thiol reductase (GILT) on the malignant phenotype of breast cancer cells. This work was performed to examine GILT expression levels and explore the potential mechanism in breast cancer.<h4>Results</h4>GILT protein expression levels were significantly lower in breast cancer cells than in normal breast epithelial cells. Overexpressing GILT inhibited breast","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-04-22T07:27:38.677Z","creation":"2025-04-05T22:08:26.174Z"},"accession":"S-EPMC11909800","cross_references":{"pubmed":["40094073"],"doi":["10.1002/cai2.161"]}}