{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25(1)"],"submitter":["Xing MW"],"pubmed_abstract":["<h4>Background</h4>Whether intraoperative isotonic balanced maintenance fluid is associated with less variation in sodium homeostasis in small children undergoing major neurosurgery remains unknown.<h4>Methods</h4>Patients aged up to 6 years undergoing major neurosurgery were randomly assigned to receive either isotonic balanced solution (IB) or 0.2% hypotonic solution (H) as intraoperative maintenance fluid. Serum electrolyte levels were measured from preoperative baseline to 6 d following surgery.<h4>Results</h4>Eighty patients were included in the primary analysis. Serum sodium change was significantly less in the IB patients from the end of surgery continuing to 24 h following surgery (at the end of surgery: -1.4 ± 3.6 versus - 4.6 ± 3.5 mmol/l, P < 0.001; 24 h post: -1.2 ± 4.8 versus "],"journal":["BMC pediatrics"],"pagination":["195"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11909862"],"repository":["biostudies-literature"],"pubmed_title":["Intraoperative isotonic balanced versus hypotonic crystalloids on postoperative sodium homeostasis in small children undergoing major neurosurgery: a randomized controlled trial."],"pmcid":["PMC11909862"],"pubmed_authors":["Wang DX","Zhang Y","Zhu HT","Song LL","Geng ZY","Liu C","Xing MW"],"additional_accession":[]},"is_claimable":false,"name":"Intraoperative isotonic balanced versus hypotonic crystalloids on postoperative sodium homeostasis in small children undergoing major neurosurgery: a randomized controlled trial.","description":"<h4>Background</h4>Whether intraoperative isotonic balanced maintenance fluid is associated with less variation in sodium homeostasis in small children undergoing major neurosurgery remains unknown.<h4>Methods</h4>Patients aged up to 6 years undergoing major neurosurgery were randomly assigned to receive either isotonic balanced solution (IB) or 0.2% hypotonic solution (H) as intraoperative maintenance fluid. Serum electrolyte levels were measured from preoperative baseline to 6 d following surgery.<h4>Results</h4>Eighty patients were included in the primary analysis. Serum sodium change was significantly less in the IB patients from the end of surgery continuing to 24 h following surgery (at the end of surgery: -1.4 ± 3.6 versus - 4.6 ± 3.5 mmol/l, P < 0.001; 24 h post: -1.2 ± 4.8 versus ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-20T00:08:31.004Z","creation":"2025-04-20T00:08:31.004Z"},"accession":"S-EPMC11909862","cross_references":{"pubmed":["40089683"],"doi":["10.1186/s12887-025-05543-6"]}}