{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pearl AJ"],"funding":["Department of Health | National Health and Medical Research Council (NHMRC)","Department of Health | National Health and Medical Research Council"],"pagination":["2568"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11910522"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Risky drinking rates are rising, particularly in women, yet sex as a biological variable has only recently gained traction. The centrally projecting Edinger-Westphal (EWcp) nucleus has emerged as a key regulator of alcohol consumption. Here we found that EWcp<sup>peptidergic</sup> cells reduce binge drinking specifically in female mice. We show this effect is mediated by the ghrelin receptor (GHSR), with EWcp<sup>peptidergic</sup> inhibition blocking ghrelin-induced drinking and Ghsr knockdown in EWcp<sup>peptidergic</sup>, but not EWcp<sup>glutamatergic</sup> or ventral tegmental area cells, reducing binge drinking in females, independent of circulating sex hormones. Female mice showed higher EWcp Ghsr expression, and EWcp<sup>peptidergic</sup> neurons were more sensitive to ghrelin. More"],"journal":["Nature communications"],"pubmed_title":["Midbrain ghrelin receptor signalling regulates binge drinking in a sex specific manner."],"pmcid":["PMC11910522"],"funding_grant_id":["2008344","2002830"],"pubmed_authors":["Reed FM","Pearl AJ","Pinares-Garcia P","Giardino WJ","Lawrence AJ","Anversa RG","Shesham A","Brown RM","Maddern XJ","Ursich LT","Walker LC"],"additional_accession":[]},"is_claimable":false,"name":"Midbrain ghrelin receptor signalling regulates binge drinking in a sex specific manner.","description":"Risky drinking rates are rising, particularly in women, yet sex as a biological variable has only recently gained traction. The centrally projecting Edinger-Westphal (EWcp) nucleus has emerged as a key regulator of alcohol consumption. Here we found that EWcp<sup>peptidergic</sup> cells reduce binge drinking specifically in female mice. We show this effect is mediated by the ghrelin receptor (GHSR), with EWcp<sup>peptidergic</sup> inhibition blocking ghrelin-induced drinking and Ghsr knockdown in EWcp<sup>peptidergic</sup>, but not EWcp<sup>glutamatergic</sup> or ventral tegmental area cells, reducing binge drinking in females, independent of circulating sex hormones. Female mice showed higher EWcp Ghsr expression, and EWcp<sup>peptidergic</sup> neurons were more sensitive to ghrelin. More","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-01T19:04:48.907Z","creation":"2025-04-04T03:04:31.408Z"},"accession":"S-EPMC11910522","cross_references":{"pubmed":["40089486"],"doi":["10.1038/s41467-025-57880-w"]}}