{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Azhakesan A"],"funding":["German Excellence Strategy","Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg","Deutsche Forschungsgemeinschaft"],"pagination":["e2403114"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11912098"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(7)"],"pubmed_abstract":["Head and neck squamous cell carcinoma (HNSCC) are invasive solid tumors accounting for high mortality. To improve the clinical outcome, a better understanding of the tumor and its microenvironment (TME) is crucial. Three -dimensional (3D) bioprinting is emerging as a powerful tool for recreating the TME in vitro. To establish long-term HNSCC bioprinted constructs for personalized drug-testing, this proof-of-principle study aims to compare two different innovative tunicate-derived nanocellulose (NC) hydrogels against the widely used semi-synthetic gelatin methacryloyl (GelMA). Cell lines of different tumor origin sites are printed in TEMPO and Carboxy-NC, and GelMA in alginate (GelMAA). Both NC hydrogels show higher bioprintability than GelMAA. Carboxy-NC supported long-term HNSCC survival,"],"journal":["Advanced healthcare materials"],"pubmed_title":["3D Bioprinted Head and Neck Squamous Cell Carcinoma (HNSCC) Model Using Tunicate Derived Nanocellulose (NC) Bioink."],"pmcid":["PMC11912098"],"funding_grant_id":["BW6_07","RTG 2154","33‐7533‐6‐1522 / 10/4","33-7533-6-1522 / 10/4","2082/1-390761711 (3D Matter Made to Order)"],"pubmed_authors":["Kern J","Rotter N","Selhuber-Unkel C","Azhakesan A","Mishra A","Gatenholm P","Bieback K","Affolter A"],"additional_accession":[]},"is_claimable":false,"name":"3D Bioprinted Head and Neck Squamous Cell Carcinoma (HNSCC) Model Using Tunicate Derived Nanocellulose (NC) Bioink.","description":"Head and neck squamous cell carcinoma (HNSCC) are invasive solid tumors accounting for high mortality. To improve the clinical outcome, a better understanding of the tumor and its microenvironment (TME) is crucial. Three -dimensional (3D) bioprinting is emerging as a powerful tool for recreating the TME in vitro. To establish long-term HNSCC bioprinted constructs for personalized drug-testing, this proof-of-principle study aims to compare two different innovative tunicate-derived nanocellulose (NC) hydrogels against the widely used semi-synthetic gelatin methacryloyl (GelMA). Cell lines of different tumor origin sites are printed in TEMPO and Carboxy-NC, and GelMA in alginate (GelMAA). Both NC hydrogels show higher bioprintability than GelMAA. Carboxy-NC supported long-term HNSCC survival,","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-05T12:39:09.028Z","creation":"2025-04-05T12:39:09.028Z"},"accession":"S-EPMC11912098","cross_references":{"pubmed":["39801216"],"doi":["10.1002/adhm.202403114"]}}