biostudies-literatureUnknownSzakmany TEconomic and Social Research CouncilHealth Data Research UKAll Wales Critical Care and Trauma Network<h4>Background</h4>We assessed the healthcare and economic burden of sepsis in adult hospitalised patients in Wales, UK.<h4>Methods</h4>We analysed hospital admissions to all acute hospitals in Wales via the Secure Anonymised Information Linkage Databank. We included all adult patients, 2006-2018, with an inpatient admission including one or more explicit sepsis codes.<h4>Results</h4>38,564 patients had at least one admission for sepsis between 2006 and 2018. Most persons (86.7%) had just one admission. 3398 patients (8.4%) were admitted to ICU. The number of admissions increased yearly over the study period from 1548 in 2006 to 8708 in 2018. The largest annual increase (141.7% compared to the previous year) occurred in 2017. Admission numbers increased disproportionately amongst patients Journal of the Intensive Care Society17511437251326774https://www.ebi.ac.uk/biostudies/studies/S-EPMC11912151biostudies-literatureAdmissions, mortality and financial burden associated with acute hospitalisations for sepsis between 2006 and 2018: A national population-level study.PMC11912151ES/S007393/1HDR-9006Szakmany TBailey RLyons RAGriffiths RPugh RHollinghurst JAkbari AfalseAdmissions, mortality and financial burden associated with acute hospitalisations for sepsis between 2006 and 2018: A national population-level study.<h4>Background</h4>We assessed the healthcare and economic burden of sepsis in adult hospitalised patients in Wales, UK.<h4>Methods</h4>We analysed hospital admissions to all acute hospitals in Wales via the Secure Anonymised Information Linkage Databank. We included all adult patients, 2006-2018, with an inpatient admission including one or more explicit sepsis codes.<h4>Results</h4>38,564 patients had at least one admission for sepsis between 2006 and 2018. Most persons (86.7%) had just one admission. 3398 patients (8.4%) were admitted to ICU. The number of admissions increased yearly over the study period from 1548 in 2006 to 8708 in 2018. The largest annual increase (141.7% compared to the previous year) occurred in 2017. Admission numbers increased disproportionately amongst patients 2025-01-01T00:00:00Z2025 Mar2026-06-04T07:51:51.406Z2025-04-04T00:08:17.302ZS-EPMC119121514010476610.1177/17511437251326774