{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu Y"],"funding":["International School of Medicine","University of Toronto Open Fellowships","Canadian Institutes of Health Research","Zhejiang University","CIHR"],"pagination":["iyaf015"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11912871"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["229(3)"],"pubmed_abstract":["The Drosophila TRIM-NHL RNA-binding protein (RBP), MEI-P26, has previously been shown to suppress tumor formation in the germline. Here we show that, in the Drosophila larval central brain, cell-type-specific expression of MEI-P26 plays a vital role in regulating neural development. MEI-P26 and another TRIM-NHL RBP, Brain tumor (BRAT), have distinct expression patterns in Type I neuroblast (NB) lineages: While both proteins are expressed in NBs, BRAT is expressed in ganglion mother cells (GMCs) but not neurons, whereas MEI-P26 is expressed in neurons but not GMCs. Knockdown of MEI-P26 leads to re-expression of the stem cell marker Deadpan (DPN) and over-production of neurons. In contrast, ectopically expressed MEI-P26 reduces NB lineage size by repressing division of GMCs, resulting in red"],"journal":["Genetics"],"pubmed_title":["The TRIM-NHL RNA-binding protein MEI-P26 modulates the size of Drosophila Type I neuroblast lineages."],"pmcid":["PMC11912871"],"funding_grant_id":["PJT-190124","Q23019","PJT-159702"],"pubmed_authors":["Yang X","Hu Y","Lipshitz HD"],"additional_accession":[]},"is_claimable":false,"name":"The TRIM-NHL RNA-binding protein MEI-P26 modulates the size of Drosophila Type I neuroblast lineages.","description":"The Drosophila TRIM-NHL RNA-binding protein (RBP), MEI-P26, has previously been shown to suppress tumor formation in the germline. Here we show that, in the Drosophila larval central brain, cell-type-specific expression of MEI-P26 plays a vital role in regulating neural development. MEI-P26 and another TRIM-NHL RBP, Brain tumor (BRAT), have distinct expression patterns in Type I neuroblast (NB) lineages: While both proteins are expressed in NBs, BRAT is expressed in ganglion mother cells (GMCs) but not neurons, whereas MEI-P26 is expressed in neurons but not GMCs. Knockdown of MEI-P26 leads to re-expression of the stem cell marker Deadpan (DPN) and over-production of neurons. In contrast, ectopically expressed MEI-P26 reduces NB lineage size by repressing division of GMCs, resulting in red","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-07-07T03:17:25.897Z","creation":"2025-04-05T12:38:56.954Z"},"accession":"S-EPMC11912871","cross_references":{"pubmed":["39854267"],"doi":["10.1093/genetics/iyaf015"]}}