{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yi ES"],"funding":["Korea University Guro Hospital","Korea University Medicine","Korean Fund for Regenerative Medicine"],"pagination":["e48"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11913628"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(10)"],"pubmed_abstract":["<h4>Background</h4>Graft failure (GF) is a major complication of allogeneic hematopoietic cell transplantation (allo-HCT). Secondary transplantation has been recognized as a potential curative intervention.<h4>Methods</h4>This study aimed to investigate the characteristics and outcomes of salvage transplantation by analyzing the patients who underwent a second HCT for GF following the initial allo-HCT between 1998 and 2020.<h4>Results</h4>Overall, 23 recipients were identified, including 14 and 9 individuals with primary and secondary GF, respectively. Nine recipients underwent a second transplant from the same donor. Familial mismatched donors predominated in the second HCT (86.9%), with reduced-intensity conditioning as the prevailing approach (60.9%). Neutrophil engraftment occurred in "],"journal":["Journal of Korean medical science"],"pubmed_title":["Second Allogeneic Hematopoietic Cell Transplantation Following Graft Failure in Children."],"pmcid":["PMC11913628"],"funding_grant_id":["K2327431","KFRM 21A0502L1"],"pubmed_authors":["Hur J","Yi ES","Sung KW","Yoo KH","Ju HY","Lee JW"],"additional_accession":[]},"is_claimable":false,"name":"Second Allogeneic Hematopoietic Cell Transplantation Following Graft Failure in Children.","description":"<h4>Background</h4>Graft failure (GF) is a major complication of allogeneic hematopoietic cell transplantation (allo-HCT). Secondary transplantation has been recognized as a potential curative intervention.<h4>Methods</h4>This study aimed to investigate the characteristics and outcomes of salvage transplantation by analyzing the patients who underwent a second HCT for GF following the initial allo-HCT between 1998 and 2020.<h4>Results</h4>Overall, 23 recipients were identified, including 14 and 9 individuals with primary and secondary GF, respectively. Nine recipients underwent a second transplant from the same donor. Familial mismatched donors predominated in the second HCT (86.9%), with reduced-intensity conditioning as the prevailing approach (60.9%). Neutrophil engraftment occurred in ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-20T00:11:22.883Z","creation":"2025-04-20T00:11:22.883Z"},"accession":"S-EPMC11913628","cross_references":{"pubmed":["40098492"],"doi":["10.3346/jkms.2025.40.e48"]}}