{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["van Dorth D"],"funding":["Dutch Research Council (NWO)"],"pagination":["281-290"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11913638"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(2)"],"pubmed_abstract":["<h4>Background</h4>Early treatment effects in patients with glioblastoma are frequently discussed during multidisciplinary team meetings (MDTM), after which a decision regarding (dis)continuation of tumor-targeted treatment is made. This study examined whether a separate and systematic evaluation of perfusion MRI (pMRI) could impact such treatment decisions in the early stage.<h4>Methods</h4>This retrospective observational study evaluated the diagnostic accuracy for detecting early tumor progression of 4 different approaches including conventional MRI, pMRI with Arterial Spin Labeling (ASL), and/or Dynamic Susceptibility Contrast (DSC) MRI, and compared those to the MDTM evaluation in clinical practice.<h4>Results</h4>Sixty-five glioblastoma patients with clinical and radiological data un"],"journal":["Neuro-oncology practice"],"pubmed_title":["Perfusion MRI-based differentiation between early tumor progression and pseudoprogression in glioblastoma and its use in clinical practice."],"pmcid":["PMC11913638"],"funding_grant_id":["17079"],"pubmed_authors":["Jiang FY","van Osch MJP","de Bresser J","Koekkoek JAF","Smits M","Schmitz-Abecassis B","van Dorth D","Taphoorn MJB","Dirven L","Croese RJI"],"additional_accession":[]},"is_claimable":false,"name":"Perfusion MRI-based differentiation between early tumor progression and pseudoprogression in glioblastoma and its use in clinical practice.","description":"<h4>Background</h4>Early treatment effects in patients with glioblastoma are frequently discussed during multidisciplinary team meetings (MDTM), after which a decision regarding (dis)continuation of tumor-targeted treatment is made. This study examined whether a separate and systematic evaluation of perfusion MRI (pMRI) could impact such treatment decisions in the early stage.<h4>Methods</h4>This retrospective observational study evaluated the diagnostic accuracy for detecting early tumor progression of 4 different approaches including conventional MRI, pMRI with Arterial Spin Labeling (ASL), and/or Dynamic Susceptibility Contrast (DSC) MRI, and compared those to the MDTM evaluation in clinical practice.<h4>Results</h4>Sixty-five glioblastoma patients with clinical and radiological data un","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2025-04-05T12:39:07.118Z","creation":"2025-04-05T12:39:07.118Z"},"accession":"S-EPMC11913638","cross_references":{"pubmed":["40110054"],"doi":["10.1093/nop/npae099"]}}