biostudies-literaturevan Dorth DDutch Research Council (NWO)281-290https://www.ebi.ac.uk/biostudies/studies/S-EPMC11913638biostudies-literatureUnknown12(2)<h4>Background</h4>Early treatment effects in patients with glioblastoma are frequently discussed during multidisciplinary team meetings (MDTM), after which a decision regarding (dis)continuation of tumor-targeted treatment is made. This study examined whether a separate and systematic evaluation of perfusion MRI (pMRI) could impact such treatment decisions in the early stage.<h4>Methods</h4>This retrospective observational study evaluated the diagnostic accuracy for detecting early tumor progression of 4 different approaches including conventional MRI, pMRI with Arterial Spin Labeling (ASL), and/or Dynamic Susceptibility Contrast (DSC) MRI, and compared those to the MDTM evaluation in clinical practice.<h4>Results</h4>Sixty-five glioblastoma patients with clinical and radiological data unNeuro-oncology practicePerfusion MRI-based differentiation between early tumor progression and pseudoprogression in glioblastoma and its use in clinical practice.PMC1191363817079Jiang FYvan Osch MJPde Bresser JKoekkoek JAFSmits MSchmitz-Abecassis Bvan Dorth DTaphoorn MJBDirven LCroese RJIfalsePerfusion MRI-based differentiation between early tumor progression and pseudoprogression in glioblastoma and its use in clinical practice.<h4>Background</h4>Early treatment effects in patients with glioblastoma are frequently discussed during multidisciplinary team meetings (MDTM), after which a decision regarding (dis)continuation of tumor-targeted treatment is made. This study examined whether a separate and systematic evaluation of perfusion MRI (pMRI) could impact such treatment decisions in the early stage.<h4>Methods</h4>This retrospective observational study evaluated the diagnostic accuracy for detecting early tumor progression of 4 different approaches including conventional MRI, pMRI with Arterial Spin Labeling (ASL), and/or Dynamic Susceptibility Contrast (DSC) MRI, and compared those to the MDTM evaluation in clinical practice.<h4>Results</h4>Sixty-five glioblastoma patients with clinical and radiological data un2025-01-01T00:00:00Z2025 Apr2025-04-05T12:39:07.118Z2025-04-05T12:39:07.118ZS-EPMC119136384011005410.1093/nop/npae099