{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Kim W"],"funding":["Yonsei University College of Medicine","National Research Foundation of Korea"],"pubmed_abstract":["<h4>Objective</h4>Graves' orbitopathy (GO) is characterized by increased production of proinflammatory cytokines and hyaluronic acid by fibroblasts and their differentiation into adipocytes in response to immunologic stimuli. The suppressor of cytokine signaling-3 (<i>SOCS3</i>) is an inducible negative regulator of the JAK/STAT pathway, implicated in various inflammatory diseases. In this study, we investigated the role of SOCS3 in the inflammatory and adipogenic pathogenesis of GO.<h4>Methods</h4>Transcriptome profiling of orbital tissues obtained from five patients with GO who underwent orbital decompression surgery and four healthy subjects was performed using RNA-sequencing. Among the top-ranked differentially expressed genes, we identified 24 hub genes and found <i>SOCS3</i> to be th"],"journal":["Frontiers in endocrinology"],"pagination":["1527275"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11913680"],"repository":["biostudies-literature"],"pubmed_title":["Role of the suppressor of cytokine signaling-3 in the pathogenesis of Graves' orbitopathy."],"pmcid":["PMC11913680"],"pubmed_authors":["Kim S","Choi SH","Ku CR","Kim W","Lee EJ","Seo MK","Kim YJ","Yoon JS"],"additional_accession":[]},"is_claimable":false,"name":"Role of the suppressor of cytokine signaling-3 in the pathogenesis of Graves' orbitopathy.","description":"<h4>Objective</h4>Graves' orbitopathy (GO) is characterized by increased production of proinflammatory cytokines and hyaluronic acid by fibroblasts and their differentiation into adipocytes in response to immunologic stimuli. The suppressor of cytokine signaling-3 (<i>SOCS3</i>) is an inducible negative regulator of the JAK/STAT pathway, implicated in various inflammatory diseases. In this study, we investigated the role of SOCS3 in the inflammatory and adipogenic pathogenesis of GO.<h4>Methods</h4>Transcriptome profiling of orbital tissues obtained from five patients with GO who underwent orbital decompression surgery and four healthy subjects was performed using RNA-sequencing. Among the top-ranked differentially expressed genes, we identified 24 hub genes and found <i>SOCS3</i> to be th","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-06T16:48:45.473Z","creation":"2025-04-05T12:39:06.991Z"},"accession":"S-EPMC11913680","cross_references":{"pubmed":["40104138"],"doi":["10.3389/fendo.2025.1527275"]}}