biostudies-literatureUnknown16Kim WYonsei University College of MedicineNational Research Foundation of Korea<h4>Objective</h4>Graves' orbitopathy (GO) is characterized by increased production of proinflammatory cytokines and hyaluronic acid by fibroblasts and their differentiation into adipocytes in response to immunologic stimuli. The suppressor of cytokine signaling-3 (<i>SOCS3</i>) is an inducible negative regulator of the JAK/STAT pathway, implicated in various inflammatory diseases. In this study, we investigated the role of SOCS3 in the inflammatory and adipogenic pathogenesis of GO.<h4>Methods</h4>Transcriptome profiling of orbital tissues obtained from five patients with GO who underwent orbital decompression surgery and four healthy subjects was performed using RNA-sequencing. Among the top-ranked differentially expressed genes, we identified 24 hub genes and found <i>SOCS3</i> to be thFrontiers in endocrinology1527275https://www.ebi.ac.uk/biostudies/studies/S-EPMC11913680biostudies-literatureRole of the suppressor of cytokine signaling-3 in the pathogenesis of Graves' orbitopathy.PMC11913680Kim SChoi SHKu CRKim WLee EJSeo MKKim YJYoon JSfalseRole of the suppressor of cytokine signaling-3 in the pathogenesis of Graves' orbitopathy.<h4>Objective</h4>Graves' orbitopathy (GO) is characterized by increased production of proinflammatory cytokines and hyaluronic acid by fibroblasts and their differentiation into adipocytes in response to immunologic stimuli. The suppressor of cytokine signaling-3 (<i>SOCS3</i>) is an inducible negative regulator of the JAK/STAT pathway, implicated in various inflammatory diseases. In this study, we investigated the role of SOCS3 in the inflammatory and adipogenic pathogenesis of GO.<h4>Methods</h4>Transcriptome profiling of orbital tissues obtained from five patients with GO who underwent orbital decompression surgery and four healthy subjects was performed using RNA-sequencing. Among the top-ranked differentially expressed genes, we identified 24 hub genes and found <i>SOCS3</i> to be th2025-01-01T00:00:00Z20252026-06-06T16:48:45.473Z2025-04-05T12:39:06.991ZS-EPMC119136804010413810.3389/fendo.2025.1527275