biostudies-literatureUnknown16Abdelnaim MA<h4>Introduction</h4>Irritable bowel syndrome (IBS) is a common condition characterized by abdominal pain and altered bowel habits, affecting around 11% of individuals globally. It is linked to dysregulation of the brain-gut axis, with altered activity and connectivity in various brain regions. IBS patients often have psychiatric comorbidities like anxiety, or obsessive-compulsive disorder (OCD). Deep brain stimulation (DBS) is an established treatment option for severe, therapy-refractory OCD. It has been suggested that DBS for OCD could also have a beneficial effect on accompanying IBS-symptoms.<h4>Methods and patients</h4>Nine patients with treatment-refractory OCD who underwent DBS in the bed nucleus striae terminalis (BNST) have been included in this study (4 males, 5 females, mean agFrontiers in psychiatry1545318https://www.ebi.ac.uk/biostudies/studies/S-EPMC11919902biostudies-literatureDeep brain stimulation for obsessive compulsive disorder leads to symptom changes of comorbid irritable bowel syndrome.PMC11919902Abdelnaim MALang-Hambauer VReissmann ALangguth BSchlaier JHebel TfalseDeep brain stimulation for obsessive compulsive disorder leads to symptom changes of comorbid irritable bowel syndrome.<h4>Introduction</h4>Irritable bowel syndrome (IBS) is a common condition characterized by abdominal pain and altered bowel habits, affecting around 11% of individuals globally. It is linked to dysregulation of the brain-gut axis, with altered activity and connectivity in various brain regions. IBS patients often have psychiatric comorbidities like anxiety, or obsessive-compulsive disorder (OCD). Deep brain stimulation (DBS) is an established treatment option for severe, therapy-refractory OCD. It has been suggested that DBS for OCD could also have a beneficial effect on accompanying IBS-symptoms.<h4>Methods and patients</h4>Nine patients with treatment-refractory OCD who underwent DBS in the bed nucleus striae terminalis (BNST) have been included in this study (4 males, 5 females, mean ag2025-01-01T00:00:00Z20252025-04-04T14:48:18.523Z2025-04-04T14:48:18.523ZS-EPMC119199024010943610.3389/fpsyt.2025.1545318