biostudies-literatureShumbayawonda EEC | Horizon 2020 Framework ProgrammeEC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)74https://www.ebi.ac.uk/biostudies/studies/S-EPMC11920111biostudies-literatureUnknown5(1)<h4>Background</h4>Increasing prevalence of metabolic dysfunction-associated liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) poses a growing healthcare burden. Noninvasive diagnostic tools to replace liver biopsy are urgently needed. We investigated the utility and cost-effectiveness of including multiparametric magnetic resonance imaging (mpMRI) to the management of adults with suspected MASLD multi-nationally.<h4>Methods</h4>RADIcAL-1, a 1:1 randomised controlled trial (standard-of-care [SoC] vs. imaging arm [IA; SoC+mpMRI]) included 802 participants from Germany, Netherlands, Portugal and UK. Wilcoxon-rank tests were used to compare access to healthcare practitioners, patient assessments and proportion of patients with a diagnosis (%diagnosis). Liver faCommunications medicineUtility and cost-effectiveness of LiverMultiScan for MASLD diagnosis: a real-world multi-national randomised clinical trial.PMC11920111719445Banerjee RLorgelly PCarolan JECuthbertson DJFrench MBeyer CByrne CDBarclay SForton DAgarwal KFraser ABackhus JMiller MHCastelo Branco MCoenraad MJLamb HJTonev DAjaz SShumbayawonda ESchaapman JJPatel JDollinger MMfalseUtility and cost-effectiveness of LiverMultiScan for MASLD diagnosis: a real-world multi-national randomised clinical trial.<h4>Background</h4>Increasing prevalence of metabolic dysfunction-associated liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) poses a growing healthcare burden. Noninvasive diagnostic tools to replace liver biopsy are urgently needed. We investigated the utility and cost-effectiveness of including multiparametric magnetic resonance imaging (mpMRI) to the management of adults with suspected MASLD multi-nationally.<h4>Methods</h4>RADIcAL-1, a 1:1 randomised controlled trial (standard-of-care [SoC] vs. imaging arm [IA; SoC+mpMRI]) included 802 participants from Germany, Netherlands, Portugal and UK. Wilcoxon-rank tests were used to compare access to healthcare practitioners, patient assessments and proportion of patients with a diagnosis (%diagnosis). Liver fa2025-01-01T00:00:00Z2025 Mar2026-06-01T10:11:39.589Z2025-04-04T14:47:39.947ZS-EPMC119201114010252810.1038/s43856-025-00796-9