biostudies-literatureKang DOKorea University GrantNational Research Foundation of Korea (NRF)National Research Foundation of Korea9391https://www.ebi.ac.uk/biostudies/studies/S-EPMC11920199biostudies-literatureUnknown15(1)Drug-coated balloon (DCB) treatment is an emerging strategy for de novo coronary artery disease (CAD), but procedural optimization remains uncertain. This study analyzed 317 patients who underwent DCB-based intervention for de novo CAD and angiographic follow-up: SR (successful, stent-like result: diameter stenosis < 20% at follow-up angiography, n = 84, 93 lesions) and Non-SR (n = 224, 358 lesions) groups. Baseline clinical and lesion characteristics were similar, except that SR lesions had larger diameter. In SR lesions, specialty balloons were more frequently utilized (p = 0.025), and maximal balloon diameter and balloon-to-artery ratio were significantly greater compared to Non-SR lesions (p < 0.001 and p = 0.008). At a median 8-month follow-up, SR lesions exhibited larger minimal lumiScientific reportsPredictors of optimal angiographic lesion outcomes in drug-coated balloon treatment for de novo coronary artery disease.PMC11920199NRF-2021R1F1A1061337RS-2023-00210960K2225581K1923481, K2022971, K2111151, and K2211921Lee JSSong WHKim SKim BKim SHHer AYShin ESKim YHAhn JCKang DOLim SYfalsePredictors of optimal angiographic lesion outcomes in drug-coated balloon treatment for de novo coronary artery disease.Drug-coated balloon (DCB) treatment is an emerging strategy for de novo coronary artery disease (CAD), but procedural optimization remains uncertain. This study analyzed 317 patients who underwent DCB-based intervention for de novo CAD and angiographic follow-up: SR (successful, stent-like result: diameter stenosis < 20% at follow-up angiography, n = 84, 93 lesions) and Non-SR (n = 224, 358 lesions) groups. Baseline clinical and lesion characteristics were similar, except that SR lesions had larger diameter. In SR lesions, specialty balloons were more frequently utilized (p = 0.025), and maximal balloon diameter and balloon-to-artery ratio were significantly greater compared to Non-SR lesions (p < 0.001 and p = 0.008). At a median 8-month follow-up, SR lesions exhibited larger minimal lumi2025-01-01T00:00:00Z2025 Mar2026-07-15T08:28:12.969Z2025-04-03T23:26:25.007ZS-EPMC119201994010245710.1038/s41598-025-92052-2