{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Yakovlev AY"],"pubmed_abstract":["<h4>Introduction</h4>Insufficiencies of the majority of targeted therapies for the most severe, life-threatening forms of COVID-19 warrant alternative, adjuvant treatment options for enhanced life maintenance that include extracorporeal blood purification and homeostasis support. The goal of the current study is to evaluate the clinical efficacy of hemoadsorption with mesoporous hypercrosslinked polystyrene beads (Efferon CT single-use cartridge) in an expanded cohort of patients with severe and critical COVID-19 resistant to antibody therapies and requiring post-therapy invasive mechanical lung ventilation (MLV) versus parameter-matched control group with no hemoadsorption.<h4>Materials and methods</h4>A single-center cohort study (NCT06402279) enrolled patients from October 2020 to Febru"],"journal":["Frontiers in medicine"],"pagination":["1491137"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11922909"],"repository":["biostudies-literature"],"pubmed_title":["Efficacy of hemoadsorption in the severe course of COVID-19."],"pmcid":["PMC11922909"],"pubmed_authors":["Pevnev AA","Trikole AI","Popov AY","Yakovlev AY","Ilyin YV","Selivanov DD","Bershadsky FF","Pisarev VM"],"additional_accession":[]},"is_claimable":false,"name":"Efficacy of hemoadsorption in the severe course of COVID-19.","description":"<h4>Introduction</h4>Insufficiencies of the majority of targeted therapies for the most severe, life-threatening forms of COVID-19 warrant alternative, adjuvant treatment options for enhanced life maintenance that include extracorporeal blood purification and homeostasis support. The goal of the current study is to evaluate the clinical efficacy of hemoadsorption with mesoporous hypercrosslinked polystyrene beads (Efferon CT single-use cartridge) in an expanded cohort of patients with severe and critical COVID-19 resistant to antibody therapies and requiring post-therapy invasive mechanical lung ventilation (MLV) versus parameter-matched control group with no hemoadsorption.<h4>Materials and methods</h4>A single-center cohort study (NCT06402279) enrolled patients from October 2020 to Febru","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-01T05:10:09.905Z","creation":"2025-04-04T00:07:41.589Z"},"accession":"S-EPMC11922909","cross_references":{"pubmed":["40115785"],"doi":["10.3389/fmed.2025.1491137"]}}