biostudies-literatureUnknown167(1)Battista FUniversità degli Studi di Firenze<h4>Background</h4>For drug-resistant mesial temporal lobe epilepsy (MTLE), surgery is recommended. There is no evidence of a seizure outcome advantage of temporal lobectomy over other strategies despite the high risks of this surgical procedure.<h4>Methods</h4>We describe a Temporal Resection guided by intraoperative stereo-electroencephalography (iSEEG) and the ¹⁸FluoroDeoxyGlucose PET (¹⁸FDG PET) (iSP-TR) to treat lesional MTLE. We avoided functional cortical areas using navigated Transcranial Magnetic Stimulation (nTMS).<h4>Conclusion</h4>iSP-TR allows for a spare brain parenchyma compared to temporal lobectomy without compromising seizure outcomes.Acta neurochirurgica82https://www.ebi.ac.uk/biostudies/studies/S-EPMC11922984biostudies-literatureThe intraoperative SEEG and &lt;sup&gt;18&lt;/sup&gt;FDG-PET tailored temporal lobe resection (iSP-TR) for the tissue-spearing surgical treatment of drug-resistant mesial temporal lobe epilepsy: how we do it.PMC11922984Battista FGrippo ADella Puppa ACarrai RfalseThe intraoperative SEEG and &lt;sup&gt;18&lt;/sup&gt;FDG-PET tailored temporal lobe resection (iSP-TR) for the tissue-spearing surgical treatment of drug-resistant mesial temporal lobe epilepsy: how we do it.<h4>Background</h4>For drug-resistant mesial temporal lobe epilepsy (MTLE), surgery is recommended. There is no evidence of a seizure outcome advantage of temporal lobectomy over other strategies despite the high risks of this surgical procedure.<h4>Methods</h4>We describe a Temporal Resection guided by intraoperative stereo-electroencephalography (iSEEG) and the ¹⁸FluoroDeoxyGlucose PET (¹⁸FDG PET) (iSP-TR) to treat lesional MTLE. We avoided functional cortical areas using navigated Transcranial Magnetic Stimulation (nTMS).<h4>Conclusion</h4>iSP-TR allows for a spare brain parenchyma compared to temporal lobectomy without compromising seizure outcomes.2025-01-01T00:00:00Z2025 Mar2025-04-18T12:50:07.411Z2025-04-06T22:12:56.895ZS-EPMC119229844010606510.1007/s00701-025-06491-x