{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["Duplan E"],"pubmed_abstract":["Several studies have shown that Parkinson's disease causative gene products, including α-synuclein (α-syn), display tight links with the tumor suppressor p53. The purpose of this study is to determine the implication of α-syn in glioblastoma development and elucidate how it elicits a tumor suppressor function. We show that the expression of α-syn, a TP53 transcriptional target and a key molecular player in Parkinson's disease, is detected in 1p/19q-codeleted and isocitrate dehydrogenase (IDH)-mutant oligodendroglioma and in IDH-wild-type glioblastoma, while reduced in glioblastoma biopsies, corroborating the link of α-syn expression with a better prognosis among all glioma patients. Accordingly, protein expression is drastically reduced in oligodendrogliomas and glioblastoma biopsies. This"],"journal":["Cell death & disease"],"pagination":["188"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11923286"],"repository":["biostudies-literature"],"pubmed_title":["α-synuclein expression in glioblastoma restores tumor suppressor function and rescues temozolomide drug resistance."],"pmcid":["PMC11923286"],"pubmed_authors":["Casimiro M","Honnorat J","Leroudier N","Idbaih A","Tanaka S","Martin L","Castel H","Checler F","Duplan E","Malleval C","Goiran T","Bernardin A","Pestell R","Alves da Costa C"],"additional_accession":[]},"is_claimable":false,"name":"α-synuclein expression in glioblastoma restores tumor suppressor function and rescues temozolomide drug resistance.","description":"Several studies have shown that Parkinson's disease causative gene products, including α-synuclein (α-syn), display tight links with the tumor suppressor p53. The purpose of this study is to determine the implication of α-syn in glioblastoma development and elucidate how it elicits a tumor suppressor function. We show that the expression of α-syn, a TP53 transcriptional target and a key molecular player in Parkinson's disease, is detected in 1p/19q-codeleted and isocitrate dehydrogenase (IDH)-mutant oligodendroglioma and in IDH-wild-type glioblastoma, while reduced in glioblastoma biopsies, corroborating the link of α-syn expression with a better prognosis among all glioma patients. Accordingly, protein expression is drastically reduced in oligodendrogliomas and glioblastoma biopsies. This","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-05T12:37:06.797Z","creation":"2025-04-05T12:37:06.797Z"},"accession":"S-EPMC11923286","cross_references":{"pubmed":["40108111"],"doi":["10.1038/s41419-025-07509-z"]}}