biostudies-literatureLiu BNIDDK NIH HHSNHLBI NIH HHSNational Cancer InstituteNCI NIH HHSNIH675-684https://www.ebi.ac.uk/biostudies/studies/S-EPMC11923372biostudies-literatureUnknown121(3)<h4>Background</h4>Lignans are polyphenolic compounds abundant in plant-based foods such as seeds, whole grains, and certain fruits and vegetables and may lead to favorable metabolic health. It remains to be elucidated regarding the role of lignan consumption in the etiology of premature deaths among individuals with diabetes.<h4>Objectives</h4>To prospectively examine the association between postdiagnosis lignan intake and mortality among individuals with type 2 diabetes (T2D).<h4>Methods</h4>We analyzed data from 2 prospective United States cohorts, the Nurses' Health Study (1984-2020) and Health Professionals Follow-up Study (1986-2022). Mean daily consumption of total and individual lignans was calculated, and postdiagnosis lignan intakes were cumulatively averaged. Multivariable-adjusThe American journal of clinical nutritionLignan Intake and Mortality Among Adults with Incident Type 2 Diabetes-Prospective Cohort Studies.PMC11923372R01 CA49449R01 ES022981U01 CA167552R01 CA67262P01 CA87969P01 CA087969U01 CA176726R01 DK120870R01 DK126698U2C DK129670R01 HL035464R01 HL034594R01 HL060712R01 HL096905R01 HL088521UM1 CA186107Wang MHu YSun QWang SLiu BRimm EBfalseLignan Intake and Mortality Among Adults with Incident Type 2 Diabetes-Prospective Cohort Studies.<h4>Background</h4>Lignans are polyphenolic compounds abundant in plant-based foods such as seeds, whole grains, and certain fruits and vegetables and may lead to favorable metabolic health. It remains to be elucidated regarding the role of lignan consumption in the etiology of premature deaths among individuals with diabetes.<h4>Objectives</h4>To prospectively examine the association between postdiagnosis lignan intake and mortality among individuals with type 2 diabetes (T2D).<h4>Methods</h4>We analyzed data from 2 prospective United States cohorts, the Nurses' Health Study (1984-2020) and Health Professionals Follow-up Study (1986-2022). Mean daily consumption of total and individual lignans was calculated, and postdiagnosis lignan intakes were cumulatively averaged. Multivariable-adjus2025-01-01T00:00:00Z2025 Mar2026-06-06T19:59:54.413Z2026-06-04T03:12:34.311ZS-EPMC119233723979866910.1016/j.ajcnut.2025.01.008