{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(3)"],"submitter":["Rhee C"],"pubmed_abstract":["<h4>Importance</h4>The Centers for Medicare & Medicaid Services Severe Sepsis and Septic Shock Management Bundle (SEP-1) is supported by observational studies that report SEP-1 compliance is associated with lower mortality. Most studies, however, adjusted for limited confounders and provided little insight into why bundle-compliant care was not provided.<h4>Objectives</h4>To identify the clinical factors that complicate the diagnosis and management of sepsis and assess their association with SEP-1 compliance and mortality.<h4>Design, setting, and participants</h4>This retrospective cohort study was conducted among 590 adults with sepsis in the emergency department of 4 academic hospitals from January 1, 2019, to December 31, 2022. Patients' medical records were reviewed between September 2"],"journal":["JAMA network open"],"pagination":["e251100"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11923707"],"repository":["biostudies-literature"],"pubmed_title":["Complex Sepsis Presentations, SEP-1 Compliance, and Outcomes."],"pmcid":["PMC11923707"],"pubmed_authors":["Filbin MR","Roach DJ","Faine BA","Train SE","Mohr NM","Park ST","Klompas M","Plechot K","Zepeski A","Rhee C","DelloStritto L","Shappell CN","Yu T","Porter E"],"additional_accession":[]},"is_claimable":false,"name":"Complex Sepsis Presentations, SEP-1 Compliance, and Outcomes.","description":"<h4>Importance</h4>The Centers for Medicare & Medicaid Services Severe Sepsis and Septic Shock Management Bundle (SEP-1) is supported by observational studies that report SEP-1 compliance is associated with lower mortality. Most studies, however, adjusted for limited confounders and provided little insight into why bundle-compliant care was not provided.<h4>Objectives</h4>To identify the clinical factors that complicate the diagnosis and management of sepsis and assess their association with SEP-1 compliance and mortality.<h4>Design, setting, and participants</h4>This retrospective cohort study was conducted among 590 adults with sepsis in the emergency department of 4 academic hospitals from January 1, 2019, to December 31, 2022. Patients' medical records were reviewed between September 2","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-03T23:26:41.675Z","creation":"2025-04-03T23:26:41.675Z"},"accession":"S-EPMC11923707","cross_references":{"pubmed":["40105841"],"doi":["10.1001/jamanetworkopen.2025.1100"]}}