biostudies-literatureUnknown8(3)Dukes KC<h4>Importance</h4>Indefinite suppressive antibiotic therapy (SAT) is sometimes prescribed after initial antibiotic treatment for prosthetic joint infection (PJI). Limited evidence on outcomes after SAT exists, and using SAT for patients at low risk who may not need it could be associated with antibiotic resistance and adverse events.<h4>Objectives</h4>To characterize clinical decision-making about SAT after PJI and identify stewardship intervention opportunities to stop or reduce SAT for patients who may not benefit.<h4>Design, setting, and participants</h4>In this qualitative study, interviews were conducted with 41 clinicians involved in decision-making about SAT after PJI at 8 US Veterans Affairs hospitals between November 1, 2019, and July 31, 2021. Analysis was conducted from June 9,JAMA network opene251152https://www.ebi.ac.uk/biostudies/studies/S-EPMC11923720biostudies-literatureDecisions About Suppressive Antibiotics Among Clinicians at Veterans Affairs Hospitals After Prosthetic Joint Infection.PMC11923720Beck BSuh DDukes KCAlexander BReisinger HSWalhof JFSekar PHockett Sherlock SMiell KRSchweizer MLPugely ASuzuki HfalseDecisions About Suppressive Antibiotics Among Clinicians at Veterans Affairs Hospitals After Prosthetic Joint Infection.<h4>Importance</h4>Indefinite suppressive antibiotic therapy (SAT) is sometimes prescribed after initial antibiotic treatment for prosthetic joint infection (PJI). Limited evidence on outcomes after SAT exists, and using SAT for patients at low risk who may not need it could be associated with antibiotic resistance and adverse events.<h4>Objectives</h4>To characterize clinical decision-making about SAT after PJI and identify stewardship intervention opportunities to stop or reduce SAT for patients who may not benefit.<h4>Design, setting, and participants</h4>In this qualitative study, interviews were conducted with 41 clinicians involved in decision-making about SAT after PJI at 8 US Veterans Affairs hospitals between November 1, 2019, and July 31, 2021. Analysis was conducted from June 9,2025-01-01T00:00:00Z2025 Mar2025-04-04T00:06:36.038Z2025-04-04T00:06:36.038ZS-EPMC119237204010583910.1001/jamanetworkopen.2025.1152