{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33(1)"],"submitter":["Leonardo-Sousa C"],"pubmed_abstract":["The dysregulation of the transforming growth factor β (TGF-β) signaling pathway plays a critical role in the onset and progression of several diseases, including cancer. Notably, TGF-β has emerged as a significant barrier to effective outcomes in cancer immunotherapies, particularly those using immune checkpoint inhibitors. In response to this challenge, small-molecule inhibitors targeting the TGF-β receptor I (TGF-βRI) have garnered attention as promising candidates for modulating the TGF-β signaling pathway. This comprehensive review focuses on the development of small-molecule inhibitors targeting TGF-βRI. We provide a detailed analysis of the structural biology of TGF-βRI, highlighting key binding interactions and structural insights derived from high-resolution X-ray crystal structure"],"journal":["Molecular therapy. Oncology"],"pagination":["200945"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11923830"],"repository":["biostudies-literature"],"pubmed_title":["Structural insights and clinical advances in small-molecule inhibitors targeting TGF-β receptor I."],"pmcid":["PMC11923830"],"pubmed_authors":["Acurcio RC","Guedes RC","Leonardo-Sousa C","Barriga R","Florindo HF"],"additional_accession":[]},"is_claimable":false,"name":"Structural insights and clinical advances in small-molecule inhibitors targeting TGF-β receptor I.","description":"The dysregulation of the transforming growth factor β (TGF-β) signaling pathway plays a critical role in the onset and progression of several diseases, including cancer. Notably, TGF-β has emerged as a significant barrier to effective outcomes in cancer immunotherapies, particularly those using immune checkpoint inhibitors. In response to this challenge, small-molecule inhibitors targeting the TGF-β receptor I (TGF-βRI) have garnered attention as promising candidates for modulating the TGF-β signaling pathway. This comprehensive review focuses on the development of small-molecule inhibitors targeting TGF-βRI. We provide a detailed analysis of the structural biology of TGF-βRI, highlighting key binding interactions and structural insights derived from high-resolution X-ray crystal structure","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-06-02T17:27:01.398Z","creation":"2025-04-05T22:09:25.701Z"},"accession":"S-EPMC11923830","cross_references":{"pubmed":["40115728"],"doi":["10.1016/j.omton.2025.200945"]}}