biostudies-literatureXiao YBasic Cutting-edge Innovation Cross Project of Suzhou Medical College of Soochow UniversityKey Technologies Research and Development ProgramScience and Technology Program of SuzhouPostdoctoral Research Foundation of ChinaBasic Research Program of Jiangsu ProvincePriority Academic Program Development (PAPD) of Jiangsu Higher Education InstitutionsChina Postdoctoral Science FoundationInternational Cooperation Project of Ningbo CityNational Natural Science Foundation of Chinae2415772https://www.ebi.ac.uk/biostudies/studies/S-EPMC11923904biostudies-literatureUnknown12(11)Stem cell implantation holds promise for enhancing bone repair, but risks of pathogen transmission and malignant cell transformation should not be ignored. Compared to stem cell implantation, recruitment of endogenous stem cells to injured sites is more critical for in situ bone regeneration. In this study, based on the acidic microenvironment of bone injury, an HG-AA_1:1-SDF-1α composite hydrogel with a dual-control intelligent switch function is developed by incorporating stromal cell-derived factor (SDF-1α), arginine carbon dots (Arg-CDs), and calcium ions (Ca²⁺) into the oxidized hyaluronic acid/gelatin methacryloyl (HG) hydrogel. The acidic microenvironment triggers the first switch (Schiff base bond is broken between HG-AA_1:1 and SDF-1α) of HG-AA<sub>1Advanced science (Weinheim, Baden-Wurttemberg, Germany)Acid-Triggered Dual-Functional Hydrogel Platform for Enhanced Bone Regeneration.PMC119239042023H013YXY230404682160423SGC202379BX202302532023TQ0235BK20240797824028002024M752326GZB20230505SZS2023043YXY23040532023YFB38102012023YFB3810200Wu JChen QLi JWang CXiao YWang HWang LHu JZhang ZMa JWang WLi BYuan XMa FfalseAcid-Triggered Dual-Functional Hydrogel Platform for Enhanced Bone Regeneration.Stem cell implantation holds promise for enhancing bone repair, but risks of pathogen transmission and malignant cell transformation should not be ignored. Compared to stem cell implantation, recruitment of endogenous stem cells to injured sites is more critical for in situ bone regeneration. In this study, based on the acidic microenvironment of bone injury, an HG-AA_1:1-SDF-1α composite hydrogel with a dual-control intelligent switch function is developed by incorporating stromal cell-derived factor (SDF-1α), arginine carbon dots (Arg-CDs), and calcium ions (Ca²⁺) into the oxidized hyaluronic acid/gelatin methacryloyl (HG) hydrogel. The acidic microenvironment triggers the first switch (Schiff base bond is broken between HG-AA_1:1 and SDF-1α) of HG-AA<sub>12025-01-01T00:00:00Z2025 Mar2025-04-05T12:38:50.308Z2025-04-05T12:38:50.308ZS-EPMC119239043986891010.1002/advs.202415772